Glatiramer acetate

被引:0
|
作者
Comi, G
Moiola, L
机构
[1] Univ Vita Salute San Raffaele, Dept Neurol, I-20132 Milan, Italy
[2] Univ Vita Salute San Raffaele, Dept Neurophysiol, I-20132 Milan, Italy
来源
NEUROLOGIA | 2002年 / 17卷 / 05期
关键词
glatiramer acetate; multiple sclerosis; experimental autoimmune encephalomyelitis; Th1/Th2; cells; relapsing-remitting; disability; magnetic resonance imaging; side effects;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Glatiramer acetate (GA) is a mixture of synthetic polypeptides composed of four aminoacids. GA is very effective in suppression of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Various mechanisms of action of GA have been proposed, but the most important is probably the induction of antigen-specific suppressor T cells. Class one clinical trials have demonstrated that GA reduces the relapse rate and the accumulation of disability in relapsingremitting (RR) MS. The positive effects on disease activity and disease progression are explained by the reduction of the number and volume of the active lesions as showed by Magnetic resonance imaging (MRI) studies. Moreover new MRI techniques suggest that GA may also have some neuroprotective effects. The drug is usually well tolerated with modest side effects. In vitro and in vivo animal studies have shown that GA is devoid of teratogenic or mutagenic effects. GA is a good alternative to interferon beta for treatment of RR-MS.
引用
收藏
页码:244 / +
页数:15
相关论文
共 50 条
  • [41] Demonstration of equivalence of a generic glatiramer acetate (Glatopa™)
    Anderson, James
    Bell, Christine
    Bishop, John
    Capila, Ishan
    Ganguly, Tanmoy
    Glajch, Joseph
    Iyer, Mani
    Kaundinya, Ganesh
    Lansing, Jonathan
    Pradines, Joel
    Prescott, James
    Cohen, Bruce A.
    Kantor, Daniel
    Sachleben, Richard
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 359 (1-2) : 24 - 34
  • [42] Is glatiramer acetate better for pregnancy in multiple sclerosis?
    Kasatkin, D. S.
    Vinogradova, T. V.
    Shitova, A. S.
    Spirin, N. N.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 357 : E307 - E308
  • [43] Glatiramer acetate (Copaxone®) therapy for multiple sclerosis
    Dhib-Jalbut, S
    PHARMACOLOGY & THERAPEUTICS, 2003, 98 (02) : 245 - 255
  • [44] Evidence for use of glatiramer acetate in multiple sclerosis
    Caramanos, Z
    Arnold, DL
    LANCET NEUROLOGY, 2005, 4 (02): : 74 - 75
  • [45] Rett Syndrome-Treatment with Glatiramer Acetate
    Djukic, A.
    Holtzer, R.
    Shinnar, S.
    Muzumdar, H.
    Rose, S.
    Mowrey, W.
    Galanopoulou, A.
    Shinnar, R.
    Jankowski, J.
    Feldman, J.
    Pillai, S.
    Moshe, S.
    ANNALS OF NEUROLOGY, 2016, 80 : S300 - S300
  • [46] Management of immediate hypersensitivity reaction to glatiramer acetate
    Emmanuelle Amsler
    Jean Eric Autegarden
    Hafida Gaouar
    Camille Frances
    Angele Soria
    European Journal of Dermatology, 2017, 27 : 92 - 95
  • [47] Monitoring Glatiramer Acetate treatment in multiple sclerosis
    Farina, C
    Hohlfeld, R
    NEUROLOGY, 2002, 58 (07) : A246 - A246
  • [48] Response to therapy: Biomarkers for glatiramer acetate treatment
    Dhib-Jalbut, S.
    MULTIPLE SCLEROSIS, 2007, 13 (02): : 289 - 289
  • [49] Neuroprotective autoimmunity: efficacy of glatiramer acetate on neurodegeneration
    Reick, C.
    Ellrichmann, G.
    Lee, D. H.
    Saft, C.
    Gold, R.
    Linker, R.
    MULTIPLE SCLEROSIS, 2009, 15 (09): : S139 - S140
  • [50] Localized panniculitis related to treatment with glatiramer acetate
    Victoria Nespereira, Maria
    Fonseca, Eduardo
    Pineyro, Francisca
    Pilar Arevalo, Maria
    Giacomodonato, Romina
    Paradela, Sabela
    Martinez, Walter
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 66 (04) : AB66 - AB66