Replacement of dimethylpyrazolyl group in 1,2,4,5-tetrazines by aliphatic alcohols and water

被引：17
|
作者：
Ishmetova, R. I. [1 ]
Latosh, N. I. [1 ]
Ganebnykh, I. N. [1 ]
Ignatenko, N. K. [1 ]
Tolshchina, S. G. [1 ]
Rusinov, G. L. [1 ]
机构：
[1] Russian Acad Sci, Postovskii Inst Organ Synth, Ural Div, Ekaterinburg 620041, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 45卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
Pyridazine; Tetrazine; Anhydrous Acetonitrile; Anhydrous Dioxane; Pyrazolyl Group;
D O I：
10.1134/S1070428009070197
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 3,6-bis(4-R-3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines and 3-amino-6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines with aliphatic alcohols and water in the presence of a base involved replacement of the dimethylpyrazolyl group and resulted in the formation of mono- and dialkoxy-1,2,4,5-tetrazines and 6-substituted 3-hydroxy-1,2,4,5-tetrazines. Dissociation constants of the latter were determined by potentiometric titration.
引用
收藏
页码：1102 / 1107
页数：6
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