Sources of impurities - Investigation of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[(2-phthalimidoethoxy) methyl]-1,4-dihydropyridine traces formation during the synthesis of amlodipine besylate

被引：0

作者：

Zmitek, J ^{[1
]}

Grahek, R ^{[1
]}

Zizek, T ^{[1
]}

Furlan, B ^{[1
]}

机构：

[1] LEK DD, Ljubljana 1526, Slovenia

来源：

ACTA CHIMICA SLOVENICA | 2000年 / 47卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

General consideration of possible sources of impurities in organic synthesis products is presented, distinguishing between primary and secondary impurities. By an investigation of impurity 3 in amlodipine besylate 1 it is shown that packaging and process equipment materials, involved in a synthesis, can be additional source of impurities. It was found that impurity 3 can be formed by reaction between amlodipine besylate 1 and bis(2-ethylhexyl) phtalate (2) eluted from plastic materials used for storage of solvents for the amlodipine besylate synthesis. A selective and sensitive HPLC-MS/MS method was developed for this investigation.

引用

页码：63 / 68

页数：6

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