Role of transforming growth factor beta in peritoneal fibrosis

被引：4
|
作者：
Al-Jayyousi, RH [1 ]
Medcalf, JF [1 ]
Harris, KP [1 ]
机构：
[1] Leicester Gen Hosp, Dept Nephrol, Renal Unit, Leicester LE5 4PW, Leics, England
来源：
NEPHROLOGY | 2002年 / 7卷 / 05期
关键词：
mesothelial cells; peritoneal fibrosis; transforming growth factor beta;
D O I：
10.1046/j.1440-1797.2002.00116.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Technique survival of peritoneal dialysis is seriously limited by the development of peritoneal fibrosis. The mesothelial cell layer lining the peritoneum is important in the pathogenesis of peritoneal fibrosis. Mesothelial cells are able to produce transforming growth factor beta (TGF-beta), and respond to stimulation by this cytokine. In this review, we will detail the evidence available so far for the role of the complex interaction between TGF-beta and mesothelial cells in the development of peritoneal fibrosis.
引用
收藏
页码：216 / 219
页数：4
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