High-Throughput Liquid-Liquid Extraction in 96-Well Format: Parallel Artificial Liquid Membrane Extraction

被引：0
|
作者：
Gjelstad, Astrid [1 ]
Andresen, Alf Terje [2 ]
Dahlgren, Anders [3 ]
Gundersen, Thomas E. [4 ]
Pedersen-Bjergaard, Stig [1 ,5 ]
机构：
[1] Univ Oslo, Sch Pharm, Oslo, Norway
[2] Vitas Analyt Serv Ltd, Oslo, Norway
[3] CTO Vitas, Oslo, Norway
[4] CRO Vitas Analyt Serv Ltd, Oslo, Norway
[5] Univ Copenhagen, Dept Pharm, Copenhagen, Denmark
来源：
LC GC NORTH AMERICA | 2017年 / 35卷 / 03期
关键词：
MICROEXTRACTION TECHNIQUES; SOLVENT-MICROEXTRACTION; ANALYTICAL-CHEMISTRY; HUMAN PLASMA;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid-liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples can be processed simultaneously in PALME, providing analyte enrichment, highly efficient sample cleanup, and direct compatibility with liquid chromatography-mass spectrometry (LC-MS). The consumption of hazardous organic solvents is also almost eliminated using PALME as the sample preparation technique. This article summarizes current experiences with PALME, based on work both in a university laboratory and in an analytical services contract laboratory.
引用
收藏
页码：192 / 196
页数：5
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