New cytotoxic halogenated sesquiterpenes from the Egyptian sea hare, Aplysia oculifera

被引：15

作者：

Hegazy, Mohamed-Elamir F. ^{[1
,2
]}

Moustfa, Alaa Y. ^{[3
]}

Mohamed, Abou El-Hamd H. ^{[4
]}

Alhammady, Montaser A. ^{[5
]}

Elbehairi, Serag Eldin I. ^{[6
]}

Ohta, Shinji ^{[7
]}

Pare, Paul W. ^{[8
]}

机构：

[1] Natl Res Ctr, Chem Med Plants Dept, Giza 12622, Egypt

[2] Natl Res Ctr, Ctr Excellence Adv Sci, Giza 12622, Egypt

[3] Sohag Univ, Fac Sci, Dept Zool, Sohag, Egypt

[4] Aswan Univ, Fac Sci, Dept Chem, Aswan, Egypt

[5] Natl Inst Oceanog & Fisheries, Red Sea Branch, Hurghada, Egypt

[6] Egyptian Org Biol Prod & Vaccines, Giza, Egypt

[7] Hiroshima Univ, Grad Sch Biosphere Sci, Higashihiroshima 7398521, Japan

[8] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 10期

关键词：

Aplysia oculifera; Opisthobranch; Halogenated sesquiterpenes; Cytotoxicity; MARINE NATURAL-PRODUCTS; DACTYLOMELA; LAURENCIA;

D O I：

10.1016/j.tetlet.2014.01.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new sesquiterpenes, oculiferane (1) and epi-obtusane (2) have been isolated and identified from an acetone extract of the digestive gland of the sea hare, Aplysia oculifera. The structures were elucidated by spectroscopic analysis including HREIMS, H-1, C-13, DEPT, H-1-H-1 COSY, HMQC, and HMBC NMR; the relative configuration was confirmed by X-ray analysis. Compounds 1 and 2 exhibited cytotoxic activity in vitro against several human cancer cell lines with IC50 values in the low mu g/ml range. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1711 / 1714

页数：4

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