IN VITRO TOCOLYTIC ACTIVITY OF 3-BENZAMIDO-1-(4-(2-METHOXYPHENYL)-PIPERAZIN-1-YL)-PROPYL-2-ISOPROPYLCARBOXAMIDE

被引：0

作者：

Lucky, Okunrobo O. ^{[1
]}

Omonkhelin, Owolabi J. ^{[2
,3
]}

机构：

[1] Univ Benin, Dept Pharmaceut Chem, Fac Pharm, Benin, Nigeria

[2] Univ Benin, Dept Pharmacol, Fac Pharm, Benin, Nigeria

[3] Univ Benin, Dept Toxicol, Fac Pharm, Benin, Nigeria

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 01期

关键词：

Tocolytic activity; preterm labor; antagonist; carboxamide; synthesis; PRETERM LABOR;

D O I：

10.1007/s11094-009-0237-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 3-benzamido-1-(4-(2-methoxyphenyl) piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) was accomplished by treating N-3-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylphthalimide with isopropylamine in dimethylformamide at room temperature. The compound was characterized spectroscopically. At concentrations of 0.05 and 0.1 mg/ml, 3-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) produced a significant inhibition of oxytocin (p < 0.05) and acetylcholine (p < 0.0001) induced contractions of the uterine smooth muscle in non-pregnant rats in a dose-dependent manner. From the results obtained it may be inferred that this compound is probably acting via muscarinic receptors.

引用

页码：16 / 18

页数：3

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