IN VITRO TOCOLYTIC ACTIVITY OF 3-BENZAMIDO-1-(4-(2-METHOXYPHENYL)-PIPERAZIN-1-YL)-PROPYL-2-ISOPROPYLCARBOXAMIDE

被引：0
|
作者：
Lucky, Okunrobo O. [1 ]
Omonkhelin, Owolabi J. [2 ,3 ]
机构：
[1] Univ Benin, Dept Pharmaceut Chem, Fac Pharm, Benin, Nigeria
[2] Univ Benin, Dept Pharmacol, Fac Pharm, Benin, Nigeria
[3] Univ Benin, Dept Toxicol, Fac Pharm, Benin, Nigeria
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 01期
关键词：
Tocolytic activity; preterm labor; antagonist; carboxamide; synthesis; PRETERM LABOR;
D O I：
10.1007/s11094-009-0237-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of 3-benzamido-1-(4-(2-methoxyphenyl) piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) was accomplished by treating N-3-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylphthalimide with isopropylamine in dimethylformamide at room temperature. The compound was characterized spectroscopically. At concentrations of 0.05 and 0.1 mg/ml, 3-benzamido-1-(4-(2-methoxyphenyl)piperazin-1-yl)-propyl-2-isopropylcarboxamide (BPC) produced a significant inhibition of oxytocin (p < 0.05) and acetylcholine (p < 0.0001) induced contractions of the uterine smooth muscle in non-pregnant rats in a dose-dependent manner. From the results obtained it may be inferred that this compound is probably acting via muscarinic receptors.
引用
收藏
页码：16 / 18
页数：3
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