Four bioactive new steroids from the soft coral Lobophytum pauciflorum collected in South China Sea

被引：5
|
作者：
Zhang, Di [1 ,2 ]
Wang, Zhe [1 ,2 ]
Han, Xiao [1 ,2 ]
Li, Xiao-Lei [1 ,2 ]
Lu, Zhong-Yu [1 ,2 ]
Dou, Bei-Bei [1 ,2 ]
Zhang, Wen-Ze [1 ,2 ]
Tang, Xu-Li [3 ]
Li, Ping-Lin [1 ,2 ]
Li, Guo-Qiang [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
[2] Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Peoples R China
[3] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 18卷
基金：
中国国家自然科学基金;
关键词：
anti-inflammatory; cytotoxicity; Lobophytum pauciflorum; soft coral; steroids; X-ray diffraction; POLYHYDROXYLATED STEROLS;
D O I：
10.3762/bjoc.18.42
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new polyhydroxylated steroids lobophysterols E-H (1-4), together with three known compounds (5-7), were isolated from the soft coral Lobophytum pauciflorum collected at Xisha Island, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and comparison with NMR data of structurally related compounds reported in the literature. The absolute configuration of 1-3 was determined by X-ray diffraction. All the compounds have assessed the cytotoxicity against HL-60, K562, and Hela cells. Compound 1 showed weak cytotoxicity against K562 cells with an IC50 value of 19.03 mu M. In addition, compound 1 also showed a moderate anti-inflammatory effect in zebrafish.
引用
收藏
页码：374 / 380
页数：7
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