Liquid chromatography-mass spectrometry in metabolite profiling

被引：7
|
作者：
Juo, Chiun-Gung [2 ]
Chiu, Daniel Tsun-Yee [3 ,4 ,5 ]
Shiao, Ming-Shi [1 ]
机构：
[1] Chang Gung Univ, Dept Life Sci, Inst Biomed Sci, Tao Yuan, Taiwan
[2] Chang Gung Univ, Mol Med Res Ctr, Tao Yuan, Taiwan
[3] Chang Gung Univ, Grad Inst Med Biotechnol, Tao Yuan, Taiwan
[4] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan
[5] Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan
来源：
BIOFACTORS | 2008年 / 34卷 / 02期
关键词：
Metabolomics; metabolite profiling; UHPLC; LC-MS; ion mobility spectroscopy;
D O I：
10.1002/biof.5520340207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in the use of liquid chromatography-mass spectrometry for the study of metabolomics are reviewed. Sample preparations of biofluids and practical aspects of ultra-high pressure liquid chromatography are discussed. Applicability of different kinds of mass spectrometers for metabolite profiling is described. New tools-ion mobility spectroscopy and automated chip-based nanoelectrospray system with potentials to be applied in the metabolomics analysis are described.
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页码：159 / 169
页数：11
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