A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

被引：2

作者：

Ladds, Marcus J. G. W. ^{[1
,2
]}

van Leeuwen, Ingeborg M. M. ^{[1
]}

Drummond, Catherine J. ^{[1
]}

Chu, Su ^{[3
]}

Healy, Alan R. ^{[4
,5
]}

Popova, Gergana ^{[1
]}

Fernandez, Andres Pastor ^{[1
]}

Mollick, Tanzina ^{[1
,2
]}

Darekar, Suhas ^{[1
,2
]}

Sedimbi, Saikiran K. ^{[1
,2
]}

Nekulova, Marta ^{[1
,6
]}

Sachweh, Marijke C. C. ^{[1
]}

Campbell, Johanna ^{[7
]}

Higgins, Maureen ^{[7
]}

Tuck, Chloe ^{[1
]}

Popa, Mihaela ^{[8
]}

Safont, Mireia Mayoral ^{[8
]}

Gelebart, Pascal ^{[8
]}

Fandalyuk, Zinayida ^{[8
]}

Thompson, Alastair M. ^{[9
]}

Svensson, Richard ^{[10
]}

Gustavsson, Anna-Lena ^{[11
]}

Johansson, Lars ^{[11
]}

Farnegardh, Katarina ^{[12
]}

Yngve, Ulrika ^{[13
]}

Saleh, Aljona ^{[13
]}

Haraldsson, Martin ^{[12
]}

D'Hollander, Agathe C. A. ^{[4
,5
]}

Franco, Marcela ^{[1
]}

Zhao, Yan ^{[14
]}

Hakansson, Maria ^{[15
]}

Walse, Bjorn ^{[15
]}

Larsson, Karin ^{[1
]}

Peat, Emma M. ^{[16
]}

Pelechano, Vicent ^{[2
]}

Lunec, John ^{[14
]}

Vojtesek, Borivoj ^{[6
]}

Carmena, Mar ^{[16
]}

Earnshaw, William C. ^{[16
]}

McCarthy, Anna R. ^{[1
]}

Westwood, Nicholas J. ^{[4
,5
]}

Arsenian-Henriksson, Marie ^{[1
]}

Lane, David P. ^{[1
,2
]}

Bhatia, Ravi ^{[3
]}

McCormack, Emmet ^{[8
,17
]}

Lain, Sonia ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SciLifeLab, Tomtebodavagen 23, SE-17121 Stockholm, Sweden

[3] Comprehens Canc Ctr, Div Hematol & Oncol, 1720 2nd Ave South,NP2540, Birmingham, AL 35294 USA

[4] Univ St Andrews, Sch Chem & Biomed Sci, Res Complex, St Andrews KY16 9ST, Fife, Scotland

[5] EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

[6] Masaryk Mem Canc Inst, RECAMO, Zluty Kopec 7, Brno 65653, Czech Republic

[7] Univ Dundee, Ninewells Hosp & Med Sch, Ctr Oncol & Mol Med, Dundee DD1 9SY, Scotland

[8] Univ Bergen, Hematol Sect, Dept Clin Sci, Ctr Canc Biomarkers,CCBIO, N-5021 Bergen, Norway

[9] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Holcombe Blvd, Houston, TX 77030 USA

[10] Uppsala Univ, Dept Pharm, Drug Optimizat & Pharmaceut Profiling Platform UD, SE-75237 Uppsala, Sweden

[11] Karolinska Inst, Dept Med Biochem & Biophys, Div Translat Med & Chem Biol, Chem Biol Consortium Sweden,Sci Life Lab, SE-17121 Stockholm, Sweden

[12] Sci Life Lab, Drug Discovery & Dev Platform, Tomtebodavagen 23, SE-17121 Solna, Sweden

[13] Uppsala Univ, Sci Life Labs, Dept Med Chem, SE-75123 Uppsala, Sweden

[14] Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[15] SAR Biostruct, SE-22381 Lund, Sweden

[16] Univ Edinburgh, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

[17] Haukeland Hosp, Haematol Sect, Dept Med, Bergen, Norway

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

D O I：

10.1038/s41467-018-04198-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The original PDF version of this Article listed the authors as “Marcus J.G.W. Ladds,” where it should have read “Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond et al.#”.

引用

页数：2

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