A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

被引：2

作者：

Ladds, Marcus J. G. W. ^{[1
,2
]}

van Leeuwen, Ingeborg M. M. ^{[1
]}

Drummond, Catherine J. ^{[1
]}

Chu, Su ^{[3
]}

Healy, Alan R. ^{[4
,5
]}

Popova, Gergana ^{[1
]}

Fernandez, Andres Pastor ^{[1
]}

Mollick, Tanzina ^{[1
,2
]}

Darekar, Suhas ^{[1
,2
]}

Sedimbi, Saikiran K. ^{[1
,2
]}

Nekulova, Marta ^{[1
,6
]}

Sachweh, Marijke C. C. ^{[1
]}

Campbell, Johanna ^{[7
]}

Higgins, Maureen ^{[7
]}

Tuck, Chloe ^{[1
]}

Popa, Mihaela ^{[8
]}

Safont, Mireia Mayoral ^{[8
]}

Gelebart, Pascal ^{[8
]}

Fandalyuk, Zinayida ^{[8
]}

Thompson, Alastair M. ^{[9
]}

Svensson, Richard ^{[10
]}

Gustavsson, Anna-Lena ^{[11
]}

Johansson, Lars ^{[11
]}

Farnegardh, Katarina ^{[12
]}

Yngve, Ulrika ^{[13
]}

Saleh, Aljona ^{[13
]}

Haraldsson, Martin ^{[12
]}

D'Hollander, Agathe C. A. ^{[4
,5
]}

Franco, Marcela ^{[1
]}

Zhao, Yan ^{[14
]}

Hakansson, Maria ^{[15
]}

Walse, Bjorn ^{[15
]}

Larsson, Karin ^{[1
]}

Peat, Emma M. ^{[16
]}

Pelechano, Vicent ^{[2
]}

Lunec, John ^{[14
]}

Vojtesek, Borivoj ^{[6
]}

Carmena, Mar ^{[16
]}

Earnshaw, William C. ^{[16
]}

McCarthy, Anna R. ^{[1
]}

Westwood, Nicholas J. ^{[4
,5
]}

Arsenian-Henriksson, Marie ^{[1
]}

Lane, David P. ^{[1
,2
]}

Bhatia, Ravi ^{[3
]}

McCormack, Emmet ^{[8
,17
]}

Lain, Sonia ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SciLifeLab, Tomtebodavagen 23, SE-17121 Stockholm, Sweden

[3] Comprehens Canc Ctr, Div Hematol & Oncol, 1720 2nd Ave South,NP2540, Birmingham, AL 35294 USA

[4] Univ St Andrews, Sch Chem & Biomed Sci, Res Complex, St Andrews KY16 9ST, Fife, Scotland

[5] EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

[6] Masaryk Mem Canc Inst, RECAMO, Zluty Kopec 7, Brno 65653, Czech Republic

[7] Univ Dundee, Ninewells Hosp & Med Sch, Ctr Oncol & Mol Med, Dundee DD1 9SY, Scotland

[8] Univ Bergen, Hematol Sect, Dept Clin Sci, Ctr Canc Biomarkers,CCBIO, N-5021 Bergen, Norway

[9] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Holcombe Blvd, Houston, TX 77030 USA

[10] Uppsala Univ, Dept Pharm, Drug Optimizat & Pharmaceut Profiling Platform UD, SE-75237 Uppsala, Sweden

[11] Karolinska Inst, Dept Med Biochem & Biophys, Div Translat Med & Chem Biol, Chem Biol Consortium Sweden,Sci Life Lab, SE-17121 Stockholm, Sweden

[12] Sci Life Lab, Drug Discovery & Dev Platform, Tomtebodavagen 23, SE-17121 Solna, Sweden

[13] Uppsala Univ, Sci Life Labs, Dept Med Chem, SE-75123 Uppsala, Sweden

[14] Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[15] SAR Biostruct, SE-22381 Lund, Sweden

[16] Univ Edinburgh, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

[17] Haukeland Hosp, Haematol Sect, Dept Med, Bergen, Norway

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

D O I：

10.1038/s41467-018-04198-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The original PDF version of this Article listed the authors as “Marcus J.G.W. Ladds,” where it should have read “Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond et al.#”.

引用

页数：2

共 50 条

[1] A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Catherine J. Drummond
Su Chu
Alan R. Healy
Gergana Popova
Andrés Pastor Fernández
Tanzina Mollick
Suhas Darekar
Saikiran K. Sedimbi
Marta Nekulova
Marijke C. C. Sachweh
Johanna Campbell
Maureen Higgins
Chloe Tuck
Mihaela Popa
Mireia Mayoral Safont
Pascal Gelebart
Zinayida Fandalyuk
Alastair M. Thompson
Richard Svensson
Anna-Lena Gustavsson
Lars Johansson
Katarina Färnegårdh
Ulrika Yngve
Aljona Saleh
Martin Haraldsson
Agathe C. A. D’Hollander
Marcela Franco
Yan Zhao
Maria Håkansson
Björn Walse
Karin Larsson
Emma M. Peat
Vicent Pelechano
John Lunec
Borivoj Vojtesek
Mar Carmena
William C. Earnshaw
Anna R. McCarthy
Nicholas J. Westwood
Marie Arsenian-Henriksson
David P. Lane
Ravi Bhatia
Emmet McCormack
Sonia Laín
Nature Communications, 9
[2] A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W.
van Leeuwen, Ingeborg M. M.
Drummond, Catherine J.
Chu, Su
Healy, Alan R.
Popova, Gergana
Fernandez, Andres Pastor
Mollick, Tanzina
Darekar, Suhas
Sedimbi, Saikiran K.
Nekulova, Marta
Sachweh, Marijke C. C.
Campbell, Johanna
Higgins, Maureen
Tuck, Chloe
Popa, Mihaela
Safont, Mireia Mayoral
Gelebart, Pascal
Fandalyuk, Zinayida
Thompson, Alastair M.
Svensson, Richard
Gustavsson, Anna-Lena
Johansson, Lars
Farnegardh, Katarina
Yngve, Ulrika
Saleh, Aljona
Haraldsson, Martin
D'Hollander, Agathe C. A.
Franco, Marcela
Zhao, Yan
Hakansson, Maria
Walse, Bjorn
Larsson, Karin
Peat, Emma M.
Pelechano, Vicent
Lunec, John
Vojtesek, Borivoj
Carmena, Mar
Earnshaw, William C.
McCarthy, Anna R.
Westwood, Nicholas J.
Arsenian-Henriksson, Marie
Lane, David P.
Bhatia, Ravi
McCormack, Emmet
Lain, Sonia
NATURE COMMUNICATIONS, 2018, 9
[3] Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Catherine J. Drummond
Su Chu
Alan R. Healy
Gergana Popova
Andrés Pastor Fernández
Tanzina Mollick
Suhas Darekar
Saikiran K. Sedimbi
Marta Nekulova
Marijke C. C. Sachweh
Johanna Campbell
Maureen Higgins
Chloe Tuck
Mihaela Popa
Mireia Mayoral Safont
Pascal Gelebart
Zinayida Fandalyuk
Alastair M. Thompson
Richard Svensson
Anna-Lena Gustavsson
Lars Johansson
Katarina Färnegårdh
Ulrika Yngve
Aljona Saleh
Martin Haraldsson
Agathe C. A. D’Hollander
Marcela Franco
Yan Zhao
Maria Håkansson
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Karin Larsson
Emma M. Peat
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William C. Earnshaw
Anna R. McCarthy
Nicholas J. Westwood
Marie Arsenian-Henriksson
David P. Lane
Ravi Bhatia
Emmet McCormack
Sonia Laín
Nature Communications, 9
[4] Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Catherine J. Drummond
Su Chu
Alan R. Healy
Gergana Popova
Andrés Pastor Fernández
Tanzina Mollick
Suhas Darekar
Saikiran K. Sedimbi
Marta Nekulova
Marijke C. C. Sachweh
Johanna Campbell
Maureen Higgins
Chloe Tuck
Mihaela Popa
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Pascal Gelebart
Zinayida Fandalyuk
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Richard Svensson
Anna-Lena Gustavsson
Lars Johansson
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Ulrika Yngve
Aljona Saleh
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Marcela Franco
Yan Zhao
Maria Håkansson
Björn Walse
Karin Larsson
Emma M. Peat
Vicent Pelechano
John Lunec
Borivoj Vojtesek
Mar Carmena
William C. Earnshaw
Anna R. McCarthy
Nicholas J. Westwood
Marie Arsenian-Henriksson
David P. Lane
Ravi Bhatia
Emmet McCormack
Sonia Laín
Nature Communications, 14
[5] Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (vol 14, 5019, 2023)
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