Genomic HLA profiles of MS in Hokkaido, Japan: important role of DPB1"0501 allele

被引：22
|
作者：
Fukazawa, T
Kikuchi, S
Sasaki, H
Yabe, I
Miyagishi, R
Hamada, T
Tashiro, K
机构：
[1] Hokuyukai Neurol Hosp, Nishi Ku, Sapporo, Hokkaido 0630802, Japan
[2] Hokkaido Univ, Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
来源：
JOURNAL OF NEUROLOGY | 2000年 / 247卷 / 03期
关键词：
multiple sclerosis; HLA-class II; HLA-DPB1; HLA-DQB1; Japanese;
D O I：
10.1007/s004150050558
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The polymorphism of the HLA class II genes was investigated in 97 patients with multiple sclerosis (MS) in Hokkaido, the northernmost main island of Japan. Of these, 80 patients were classified as having conventional MS and 17 as having opticospinal MS (OS-MS). Our findings confirmed a previous report that the DPB1*0501 allele is positively associated with OS-MS (P = 0.0043). The frequency of DPB1*0501 was also found to be higher in conventional MS patients than in controls (79% vs. 58%, P = 0.0084), although the differences were not statistically significant. Our results indicate that OS-MS is a DPB1*0501-associated subgroup of MS, and that DPB1*0501 is also correlated with risk of conventional MS in Japanese.
引用
收藏
页码：175 / 178
页数：4
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