Adenosine deaminase polymorphisms at the protein and DNA levels

被引：0
|
作者：
Santos, F
Amorim, A
Rocha, J
Kömpf, J
机构：
[1] Univ Porto, Inst Patol & Imunol Mol, P-4200 Oporto, Portugal
[2] Univ Porto, Fac Ciencias, P-4050 Porto, Portugal
[3] Univ Tubingen, Inst Anthropol & Human Genet, D-72074 Tubingen, Germany
来源：
HUMAN BIOLOGY | 1999年 / 71卷 / 06期
关键词：
adenosine deaminase; linkage; population genetics; Portugal; Germany;
D O I：
暂无
中图分类号：
Q98 [人类学];
学科分类号：
030303 ;
摘要：
Adenosine deaminase (ADA, E.C. 3.5.4.4) exhibits a well-known polymorphism at the protein level. We have studied ADA and an STR polymorphism exhibiting variation of a TTTA repeat motif at intron 3 of the ADA gene in random samples from northern Portugal (N = 218) and southwestern Germany (N = 114). The ADA phenotype distribution and population data on the worldwide distribution of ADA favor recurrent mutation as an explanation for the maintenance of the ADA*2 gene product at polymorphic frequencies.
引用
收藏
页码：1009 / 1013
页数：5
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