Negishi Cross-Coupling Reaction as a Route to Isocombretastatins

被引：8

作者：

Malysheva, Yulia B. ^{[1
]}

Buchvalova, Svetlana Y. ^{[1
]}

Svirshchevskaya, Elena V. ^{[2
]}

Fokin, Valery V. ^{[3
]}

Fedorov, Alexey Y. ^{[1
]}

机构：

[1] Lobachevsky State Univ Nizhni Novgorod, Dept Organ Chem, Nizhnii Novgorod 603950, Russia

[2] Russian Acad Sci, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Moscow 117997, Russia

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

SYNLETT | 2013年 / 24卷 / 14期

基金：

俄罗斯基础研究基金会;

关键词：

isocombretastatins; antitubulin agents; turbo Grignard reagent; Negishi cross-coupling; cytotoxicity; COMBRETASTATIN A-4 ANALOGS; BIOLOGICAL EVALUATION; 4-ARYLCOUMARIN ANALOGS; ANTINEOPLASTIC AGENTS; SUZUKI-MIYAURA; TUBULIN; MICROTUBULE; HALIDES; 1,1-DIARYLETHYLENES; CHEMISTRY;

D O I：

10.1055/s-0033-1339334

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 nM) towards Jurkat, K562, Colo357, and A549 cell lines.

引用

页码：1772 / 1776

页数：5

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