Exhaustive physical exercise increases frequency of micronuclei

被引：36

作者：

Schiffl, C ^{[1
]}

Zieres, C ^{[1
]}

Zankl, H ^{[1
]}

机构：

[1] UNIV KAISERSLAUTERN,DEPT HUMAN BIOL & HUMAN GENET,D-67663 KAISERSLAUTERN,GERMANY

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1997年 / 389卷 / 2-3期

关键词：

micronucleus; DNA damage; physical exercise;

D O I：

10.1016/S1383-5718(96)00154-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Micronucleus (MN) tests were performed on PHA-stimulated blood lymphocytes of six healthy volunteers before and after two exhaustive sprints, causing lactate concentrations in the peripheral blood between 9.6 and 12.4 mmol/l. The number of micronuclei was significantly increased after 24-48 h in all six subjects. The mean of the total group increased from 37 MN per 3000 binucleated cells before exercise to 56 and 55 MN 24 and 38 h after exercise, respectively. These differences were also significant. These results indicate that exhaustive physical exercise causes severe mutations at the chromosome level in blood lymphocytes.

引用

页码：243 / 246

页数：4

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