Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

被引：36

作者：

Bischof, Joachim ^{[1
]}

Westhoff, Mike-Andrew ^{[2
]}

Wagner, Johanna Elisabeth ^{[3
]}

Halatsch, Marc-Eric ^{[3
]}

Trentmann, Stephanie ^{[1
]}

Knippschild, Uwe ^{[1
]}

Wirtz, Christian Rainer ^{[2
,3
]}

Burster, Timo ^{[3
]}

机构：

[1] Ulm Univ, Surg Ctr, Med Ctr, Dept Gen & Visceral Surg, Ulm, Germany

[2] Ulm Univ, Med Ctr, Dept Pediat & Adolescent Med, Ulm, Germany

[3] Ulm Univ, Med Ctr, Surg Ctr, Dept Neurosurg, Albert Einstein Allee 23, D-89081 Ulm, Germany

来源：

TUMOR BIOLOGY | 2017年 / 39卷 / 03期

关键词：

Major histocompatibility complex class I; cathepsin; glioblastoma; autophagy; MHC CLASS-I; LYSOSOMAL PROTEIN-DEGRADATION; ACUTE MYELOID-LEUKEMIA; PROSPECTIVE IDENTIFICATION; GLIOMA PROGRESSION; MALIGNANT GLIOMAS; SIDE POPULATION; GENE-EXPRESSION; TUMOR INVASION; S EXPRESSION;

D O I：

10.1177/1010428317692227

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.

引用

页码：1 / 13

页数：13

共 50 条

[31] Colorectal Cancer Biomarkers and the Potential Role of Cancer Stem Cells
Langan, Russell C.
Mullinax, John E.
Raiji, Manish T.
Upham, Trevor
Summers, Thomas
Stojadinovic, Alexander
Avital, Itzhak
JOURNAL OF CANCER, 2013, 4 (03): : 241 - 250
[32] Glioblastoma stem cells resistant to temozolomide-induced autophagy
FU Jun LIU Zhigang LIU Xiaomei CHEN Furong SHI Hongliu PANG Jesse Chungsean NG Hokeung CHEN Zhongping State Key Laboratory for Cancer Research in Southern China and Department of NeurosurgeryNeurooncologyCancer CenterSun Yatsen UniversityGuangzhouGuangdong ChinaDepartment of Anatomical Cellular PathologyChinese University of Hong KongShatinNTHong KongChina
中华医学杂志（英文版）, 2009, (11) : 1255 - 1259
[33] Glioblastoma stem cells resistant to temozolomide-induced autophagy
Fu Jun
Liu Zhi-gang
Liu Xiao-mei
Chen Fu-rong
Shi Hong-liu
Pang, Jesse Chung-sean
Ng, Ho-keung
Chen Zhong-ping
CHINESE MEDICAL JOURNAL, 2009, 122 (11) : 1255 - 1259
[34] The role of autophagy in the metabolism and differentiation of stem cells
Adelipour, Maryam
Saleth, Leena Regi
Ghavami, Saeid
Alagarsamy, Keshav Narayan
Dhingra, Sanjiv
Allameh, Abdolamir
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2022, 1868 (08):
[35] Tissue stem cells and cancer stem cells: potential implications for gastric cancer
Gumucio, D. L.
Fagoonee, S.
Qiao, X. T.
Liebert, M.
Merchant, J. L.
Altruda, F.
Rizzetto, M.
Pellicano, R.
PANMINERVA MEDICA, 2008, 50 (01) : 65 - 71
[36] Role of Diet in Stem and Cancer Stem Cells
Puca, Francesca
Fedele, Monica
Rasio, Debora
Battista, Sabrina
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (15)
[37] Glioblastoma stem cells
Tabatabai, Ghazaleh
Weller, Michael
CELL AND TISSUE RESEARCH, 2011, 343 (03) : 459 - 465
[38] Glioblastoma stem cells
Ghazaleh Tabatabai
Michael Weller
Cell and Tissue Research, 2011, 343 : 459 - 465
[39] A major role for microRNAs in glioblastoma cancer stem-like cells
Yang, Hong Wei
Xing, Hongyan
Johnson, Mark D.
ARCHIVES OF PHARMACAL RESEARCH, 2015, 38 (03) : 423 - 434
[40] A major role for microRNAs in glioblastoma cancer stem-like cells
Hong Wei Yang
Hongyan Xing
Mark D. Johnson
Archives of Pharmacal Research, 2015, 38 : 423 - 434

← 1 2 3 4 5 →