Triple negative breast cancer in the era of miRNA

被引：50

作者：

Sabit, Hussein ^{[1
]}

Cevik, Emre ^{[1
]}

Tombuloglu, Huseyin ^{[1
]}

Abdel-Ghany, Shaimaa ^{[2
]}

Tombuloglu, Guzin ^{[3
]}

Esteller, Manel ^{[4
,5
,6
,7
]}

机构：

[1] Imam Abdulrahman Bin Faisal Univ, Inst Med Res & Consultat, Dept Genet, POB 1982, Dammam 31441, Saudi Arabia

[2] Misr Univ Sci & Technol, Coll Biotechnol, Dept Environm Biotechnol, POB 77, Giza, Egypt

[3] AdnanKahveci Mah, Mavisu Evl,7-28 Beylikduzu, Istanbul, Turkey

[4] Josep Carreras Leukemia Res Inst IJC, Barcelona, Catalonia, Spain

[5] Ctr Invest Biomed Red Canc CIBERONC, Madrid 28029, Spain

[6] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain

[7] Univ Barcelona UB, Sch Med & Hlth Sci, Dept Physiol Sci, Barcelona, Catalonia, Spain

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 157卷

关键词：

Triple negative breast cancer; MicroRNAs; Epigenomics; Neoplasm; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION; PARP INHIBITORS; EPIGENETIC REGULATION; PROMOTES INVASION; CERVICAL-CANCER; E-CADHERIN; IN-VITRO; CELLS; METASTASIS;

D O I：

10.1016/j.critrevonc.2020.103196

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this review is to elucidate the role of miRNAs in triple negative breast cancer (TNBC). To achieve our goal, we searched databases such as PubMed, ScienceDirect, Springer, Web of Science and Scopus. We retrieved up to 1233 articles, based a rigorous selection criterion, only 197 articles were extensively reviewed. We selected articles only addressing TNBC, but not other types of breast cancer, with the employed approach being miRNA analysis and/or profiling. Our extensive review resulted in grouping of miRNAs into categories in which specific members of miRNAs have roles in specific mechanism in TNBC i.e., carcinogenesis, invasion, metastasis, apoptosis, diagnosis, prognosis, and treatment. TNBC is an aggressive subtype of breast cancer; therefore, different approaches for accurate diagnosis, prognosis and treatment are needed. In this review we summarize the up-to-date miRNA profiling, prognostic, and therapeutic findings that add to the route of controlling TNBC.

引用

页数：12

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