COVID-19 vaccine (mRNA BNT162b2) and COVID-19 infection-induced thrombotic thrombocytopenic purpura in adolescents

被引：7
|
作者：
Vorster, Luna [1 ]
Kirk, Susan E. [2 ]
Muscal, Eyal [3 ,4 ]
Despotovic, Jenny M. [2 ]
Cohen, Clay T. [2 ]
Sartain, Sarah E. [2 ]
机构：
[1] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[2] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Hematol Oncol, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Rheumatol, Houston, TX USA
[4] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Neurol Dev Neurosci, Houston, TX USA
来源：
PEDIATRIC BLOOD & CANCER | 2022年 / 69卷 / 06期
关键词：
acquired TTP; COVID-19; TTP; vaccination; ADAMTS13;
D O I：
10.1002/pbc.29681
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The mRNA COVID-19 vaccine and COVID-19 infection caused by the SARS-CoV-2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID-19 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID-19 vaccine or after COVID-19 infection. Our observations demonstrate that the Pfizer-BioNTech mRNA vaccine and COVID-19 infection can act as triggers for the development/relapse of both congenital and acquired TTP.
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页数：4
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