Mesenchymal Stem Cells in Regenerative Medicine for Musculoskeletal Diseases: Bench, Bedside, and Industry

被引：62

作者：

Wei, Chih-Chang ^{[1
]}

Lin, Andrew Boyd ^{[2
]}

Hung, Shih-Chieh ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Taipei Vet Gen Hosp, Stem Cell Lab, Dept Med Res & Educ, Taipei, Taiwan

[2] Case Western Reserve Univ, Dept Biol, Cleveland, OH 44106 USA

[3] Taipei Vet Gen Hosp, Taipei, Taiwan

[4] Taipei Vet Gen Hosp, Dept Med Res, Taipei, Taiwan

[5] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Inst Pharmacol, Fac Med, Taipei 112, Taiwan

[7] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

来源：

CELL TRANSPLANTATION | 2014年 / 23卷 / 4-5期

关键词：

Mesenchymal stem cells (MSCs); Musculoskeletal diseases (MSDs); Preclinical animal studies; Clinical trials; Industry; MARROW STROMAL CELLS; THERAPY POSITION STATEMENT; BONE-MARROW; IN-VITRO; CONDITIONED MEDIUM; CARTILAGE DEFECTS; OSTEOGENESIS IMPERFECTA; INTERNATIONAL-SOCIETY; ARTICULAR-CARTILAGE; MUSCLE-FIBER;

D O I：

10.3727/096368914X678328

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human bone marrow-derived mesenchymal stem cells (MSCs) can self-renew and differentiate into osteoblasts, chondrocytes, and adipocytes. MSCs have effectively emerged as a promising tool for clinical applications, specifically in musculoskeletal diseases. This article reviews the status of preclinical animal studies, clinical trials, and the efforts of the industry in using MSCs to treat musculoskeletal diseases such as bone fractures, bone defects, focal chondral lesions, osteoarthritis, spinal diseases, and tendon injuries. We also discuss the current problems encountered and potential of using MSCs in future clinical studies.

引用

页码：505 / 512

页数：8

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