Metabolism and excretion of asoprisnil, a novel selective progesterone receptor modulator, in healthy female subjects

被引:0
|
作者
Lee, Ronald
Grabowski, Brian
Mulford, Darcy
Castagnoli, Neal
Rottmann, Antje
Chwalisz, Kristof
机构
[1] TAP Pharmaceut Prod Inc, DMPK, Lake Forest, IL USA
[2] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[3] Schering AG, Pharmacokinet Metab & Bioanalysis, D-1000 Berlin, Germany
[4] TAP Pharmaceut Prod Inc, Womens Hlth, Lake Forest, IL USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
268
引用
收藏
页码:172 / 173
页数:2
相关论文
共 50 条
  • [21] Pharmacokinetics and safety of the selective progesterone receptor modulator vilaprisan in healthy postmenopausal women
    Schultze-Mosgau, Marcus-Hillert
    Schuett, Barbara
    Hafner, Frank-Thorsten
    Zollmann, Frank
    Kaiser, Andreas
    Hoechel, Joachim
    Rohde, Beate
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2017, 55 (01) : 16 - 24
  • [22] Uterine NK Cells Regulate Endometrial Bleeding in Women and Are Suppressed by the Progesterone Receptor Modulator Asoprisnil
    Wilkens, Julia
    Male, Victoria
    Ghazal, Peter
    Forster, Thorsten
    Gibson, Douglas A.
    Williams, Alistair R. W.
    Brito-Mutunayagam, Savita L.
    Craigon, Marie
    Lourenco, Paula
    Cameron, Iain T.
    Chwalisz, Kristof
    Moffett, Ashley
    Critchley, Hilary O. D.
    JOURNAL OF IMMUNOLOGY, 2013, 191 (05): : 2226 - 2235
  • [23] Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat
    Mountfield, RJ
    Kiehr, B
    John, BA
    DRUG METABOLISM AND DISPOSITION, 2000, 28 (05) : 503 - 513
  • [24] Absorption, metabolism, and excretion of the antiemetic rolapitant, a selective neurokinin-1 receptor antagonist, in healthy male subjects
    Zhang, Zhi-Yi
    Wang, Jing
    Kansra, Vikram
    Wang, Xiaodong
    INVESTIGATIONAL NEW DRUGS, 2019, 37 (01) : 139 - 146
  • [25] Absorption, metabolism, and excretion of the antiemetic rolapitant, a selective neurokinin-1 receptor antagonist, in healthy male subjects
    Zhi-Yi Zhang
    Jing Wang
    Vikram Kansra
    Xiaodong Wang
    Investigational New Drugs, 2019, 37 : 139 - 146
  • [26] The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata
    Williams, A. R. W.
    Critchley, H. O. D.
    Osei, J.
    Ingamells, S.
    Cameron, I. T.
    Han, C.
    Chwalisz, K.
    HUMAN REPRODUCTION, 2007, 22 (06) : 1696 - 1704
  • [27] Pharmacokinetics and Safety of the Selective Progesterone Receptor Modulator Vilaprisan in Chinese Healthy Postmenopausal Women
    Liu, Hongzhong
    Jiang, Ji
    Chen, Zhaozhao
    Zhang, Yunhui
    Li, Jinyi
    Hoechel, Joachim
    Rohde, Beate
    Zimmermann, Torsten
    Schultze-Mosgau, Marcus-Hillert
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (05): : 486 - 493
  • [28] Absorption, excretion, and metabolism of the endothelin receptor antagonist bosentan in healthy male subjects
    Weber, C
    Gasser, R
    Hopfgartner, G
    DRUG METABOLISM AND DISPOSITION, 1999, 27 (07) : 810 - 815
  • [29] Metabolism and Excretion of Asenapine in Healthy Male Subjects
    van de Wetering-Krebbers, S. F. M.
    Jacobs, P. L.
    Kemperman, G. J.
    Spaans, E.
    Peeters, P. A. M.
    Delbressine, L. P. C.
    van Iersel, M. L. P. S.
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (04) : 580 - 590
  • [30] PROGESTERONE METABOLISM IN HEALTHY AND INFLAMED FEMALE GINGIVA
    HARRI, MP
    OJANOTKO, AO
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1978, 9 (09): : 826 - 826