Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long-term follow-up

被引：43
|
作者：
Tavella, A
Bergamasco, B
Bosticco, E
Lanotte, M
Perozzo, P
Rizzone, M
Torre, E
Lopiano, L
机构：
[1] Univ Turin, Dept Neurosci, I-10126 Turin, Italy
[2] IRCCS, Salvatore Maugeri Fdn, Pavia, Italy
[3] CTO Hosp, Dept Neurosurg, Turin, Italy
来源：
NEUROLOGICAL SCIENCES | 2002年 / 23卷 / Suppl 2期
关键词：
Levodopa; Deep Brain Stimulation; Motor Symptom; Assessment Program; Subthalamic Nucleus;
D O I：
10.1007/s100720200094
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective therapy for the treatment of advanced Parkinson's disease (PD). Forty-seven patients were bilaterally implanted for STN DBS and clinically evaluated according to the Core Assessment Program for Intracerebral Transplantations before surgery and 3, 12 and 24 months after surgery. Electrical stimulation led to a significant improvement in motor symptoms and in the quality of life, allowing a significant reduction of dopaminergic drugs with a consequent improvement of drug-induced dyskinesias. Statistical differences were observed between UDRS parts 11, 111 and IV values and daily levodopa dosage in the pre- and postoperative periods, while no differences were evident between the 3 postoperative conditions.
引用
收藏
页码：S111 / S112
页数：2
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