Sulfur-mediated synthesis of substituted tetrahydrofurans:: Application to the synthesis of goniofufurone

被引：0
|
作者：
Fernandez de la Pradilla, Roberto
Fernandez, Jorge
Viso, Alma
Fernandez, Javier
Gomez, Antonio
机构：
[1] CSIC, Inst Quim Organ, E-28006 Madrid, Spain
[2] Johnson & Johnson Pharmaceut Res & Dev, Div Janssen Cilag, Dept Med Chem, Toledo 45007, Spain
来源：
HETEROCYCLES | 2006年 / 68卷 / 08期
关键词：
sulfonyl oxirane; intramolecular Michael addition; tetrahydrofuran; Grignard addition; goniofufurone;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient strategy for the synthesis of densely functionalized 2,5-trans-disubstituted-tetrahydrofurans (4), from sulfinyldienols is described. Further transformations of this substrate have resulted in a new synthesis of goniofufurone (1) by means of silylated lactone (11), also readily available from D-xylose.
引用
收藏
页码：1579 / 1584
页数：6
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