Influence of Soy Isoflavone on Lindane Cumulant in Sprague-Dawley Rats

被引：1

作者：

Yang Yang ^{[1
]}

Zhang Yun Bo ^{[1
]}

Sheng Wei ^{[1
]}

Fu Zheng Hai ^{[1
]}

Wang Zhe ^{[1
]}

Wang Xiao ^{[1
]}

Guan Si Yuan ^{[2
]}

Na Xiao Lin ^{[1
]}

机构：

[1] Harbin Med Univ, Coll Publ Hlth, Dept Environm Hyg, Harbin 150086, Heilongjiang, Peoples R China

[2] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2014年 / 27卷 / 08期

关键词：

D O I：

10.3967/bes2014.097

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks. Soy isoflavones was added in feed and lindane was given by oral gavage. We found that soy isoflavones could reduce the level of lindane in rat's serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat's body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat's uterus.

引用

页码：637 / 640

页数：4

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