Pyrrolo[2,3-d]pyrimidine nucleosides:: Synthesis and antitumor activity of 7-substituted 7-deaza-2′-deoxyadenosines

被引：7
|
作者：
Seela, F
Zulauf, M
Chen, SF
机构：
[1] Univ Osnabruck, Inst Chem, Organ & Bioorgan Chem Lab, D-49069 Osnabruck, Germany
[2] Piedmont Res Ctr, Morrisville, NC 27560 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 1-2期
关键词：
D O I：
10.1080/15257770008033006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A one step synthesis, using the nucleoside 7-iodo-2'-deoxytubercidin (2b) in a Pd(0)/Cu(I)-catalyzed cross coupling reaction furnished a series of 7-alkynyl-2'-deoxytubercidin derivatives. The 7-iodo-, 7-chloro- or 7-bromo 2'-deoxytubercidins 2b-d as well as certain 7-alkynyl derivatives show significant activity against several tumor cell lines, with 7-iodo-2'-deoxytubercidin (2b) as the most effective compound.
引用
收藏
页码：237 / 251
页数：15
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