High Prevalence of Germline DNA-Repair Defects (DRD) in Advanced Cancer Patients Detected Through Precision Medicine Program

被引：0

作者：

Sailer, Verena ^{[1
]}

Zhang, Tuo ^{[1
]}

Mosquera, Juan Miguel ^{[1
]}

Pisapia, David J. ^{[1
]}

Pauli, Chantal ^{[1
]}

Robinson, Brian ^{[1
]}

Rao, Rema A. ^{[1
]}

Cyrta, Joanna ^{[1
]}

Kim, Rob ^{[1
]}

McNarty, Terra J. ^{[1
]}

Schiffman, Marc H. ^{[1
]}

Nanus, David M. ^{[1
]}

Tagawa, Scott T. ^{[1
]}

Sboner, Andrea ^{[1
]}

Elemento, Olivier ^{[1
]}

Beltran, Himisha ^{[1
]}

Rubin, Mark A. ^{[1
]}

机构：

[1] Weill Cornell Med, New York, NY USA

来源：

MODERN PATHOLOGY | 2017年 / 30卷

关键词：

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

1857

引用

页码：462A / 462A

页数：1

共 43 条

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[32] Cyclin-Dependent Kinase 4/6=Inhibitor Outcomes in Patients With Advanced Breast Cancer Carrying Germline Pathogenic Variants in DNA Repair-Related Genes
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[33] Prostatakarzinom-Biomarkerstudie zur Bestimmung der Häufigkeit von DNA-Reparaturdefekten bei Männern mit metastasiertem Prostatakarzinom – PREVALENCEProstate cancer biomarker study to determine the frequency of DNA-repair defects in men with metastatic prostate cancer—PREVALENCE
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[34] Impact of germline DNA-repair gene BRCA2 and CHEK2 mutations on time to castration resistance in patients with metastatic hormone-naive prostate cancer: A single center analysis.
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[35] Health-related quality of life in GALAHAD: A multicenter, open-label, phase 2 study of niraparib for patients with metastatic castration-resistant prostate cancer and DNA-repair gene defects
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[36] Real-world prevalence of homologous recombination repair gene (BRCA1/2 and ATM) mutations (HRRm) in patients (pts) with advanced prostate cancer (aPC) as detected by comprehensive genomic profiling (CGP) of circulating cell-free DNA (cfDNA)
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[37] Efficacy of neoadjuvant docetaxel plus cisplatin chemo-hormonal therapy versus docetaxel chemo-hormonal therapy in patients with locally advanced prostate cancer with germline DNA damage repair gene alterations
Chi, Chenfei
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THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2022, 14
[38] Laboratory -Prostate cancer High prevalence of DNA damage repair gene defects and TP53 alterations in men with treatment-na??ve metastatic prostate cancer ?Results from a prospective pilot study using a 37 gene panel
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[39] Canadian cancer trials group trial IND.231: A phase 1 trial evaluating CX-5461, a novel first-in-class G-quadruplex stabilizer in patients with advanced solid tumors enriched for DNA-repair deficiencies
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[40] Phase II trial of pembrolizumab for patients suffering from metastatic castration resistant prostate cancer (mCRPC) with DNA repair defects, high tumour mutation burden, and/or high CD3 counts (PERSEUS1).
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