A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells

被引：0
|
作者：
Luna-Gutierrez, Myrna [1 ,2 ]
Ferro-Flores, Guillermina [1 ]
Ocampo-Garcia, Blanca E. [1 ]
Santos-Cuevas, Clara L. [1 ]
Jimenez-Mancilla, Nallely [1 ,2 ]
De Leon-Rodriguez, L. M. [3 ]
Azorin-Vega, Erika [1 ]
Isaac-Olive, Keila [2 ]
机构：
[1] Inst Nacl Invest Nucl, Dept Mat Radiactivos, Toluca, Estado De Mexic, Mexico
[2] Univ Autonoma Estado Mexico, Fac Med, Toluca, Estado De Mexic, Mexico
[3] Univ Guanajuato, Dept Quim, Guanajuato, Mexico
来源：
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY | 2013年 / 57卷 / 03期
关键词：
gold nanoparticles; radiolabeled nanoparticles; radio-gold nanoparticles; radiolabeled peptides; nanoparticle-peptide; RGD peptide; lutetium-177; IN-VITRO; PEPTIDES; LIGANDS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this research was to evaluate the in vitro potential of Lu-177-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides (Lu-177-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the presence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 C, compared to 40.3 C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with Lu-177-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited.
引用
收藏
页码：212 / 219
页数：8
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