Synthesis and insecticidal activity of some 1,3,4-oxadiazole derivatives containing phenoxyfluorophenyl group

被引：0
|
作者：
Mohan, TP
Vishalakshi, B [1 ]
Bhat, KS
Rao, KS
Kendappa, GN
机构：
[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangothri 574199, India
[2] Rallis Res Ctr, Bangalore 560058, Karnataka, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2004年 / 43卷 / 08期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a few 1,3,4-oxadiazoles 5a-e is described. 4-Fluoro-3-phenoxybenzoic acid 2 is prepared starting from 4-Fluoro-3-phenoxybenzaldehyde 1. Esterification of 2 with methanol in the presence of H2SO4 gives the corresponding ester 3. Hydrazinolysis of 3 with hydrazine hydrate results in acid hydrazide 4. Hydrazide on reaction with aryl acid chlorides in presence of POCl3 affords oxadiazoles 5a-e. The compounds 5b-e manifest low insecticidal activity against certain crop pests.
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页码：1798 / 1801
页数：4
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