Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture

被引：18
|
作者：
JurimaRomet, M
Neigh, S
Casley, WL
机构：
[1] Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 1997年 / 16卷 / 04期
关键词：
cytochrome P450; retinoids; hepatocytes; rat;
D O I：
10.1177/096032719701600407
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
1 Rat hepatocytes cultured on a Matrigel matrix were exposed for 48 h to all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid or fenretinide, 2 Cytochrome P450 3A (CYP3A) RNA levels were increased by approximately eightfold in hepatocytes treated with the retinoids compared to control cultures. 3 CYP1A1 and CYP1A2 RNA levels were only slightly affected or unaffected by the retinoids. 4 The induction of CYP3A by these therapeutically-useful retinoids suggests that they may share a common mechanism for accelerated drug catabolism and acquired clinical resistance.
引用
收藏
页码：198 / 203
页数：6
相关论文
共 50 条
  • [31] Cytochrome P450 3A polymorphisms and immunosuppressive drugs:: an update
    Anglicheau, Dany
    Legendre, Christophe
    Beaune, Philippe
    Thervet, Eric
    PHARMACOGENOMICS, 2007, 8 (07) : 835 - 849
  • [32] Cytochrome P450 3A pharmacogenetics: the road that needs traveled
    Flockhart, DA
    Rae, JM
    PHARMACOGENOMICS JOURNAL, 2003, 3 (01): : 3 - 5
  • [33] EFFECT OF CANNABIDIOL (CBD) ON CYTOCHROME P450 3A IN THE MOUSE
    BORNHEIM, LM
    EVERHART, ET
    LI, J
    FASEB JOURNAL, 1993, 7 (03): : A265 - A265
  • [34] Estrogen regulation of the cytochrome P450 3A subfamily in humans
    Williams, ET
    Leyk, M
    Wrighton, SA
    Davies, PJA
    Loose, DS
    Shipley, GL
    Strobel, HW
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (02): : 728 - 735
  • [35] Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level
    Cotreau, MM
    von Moltke, LL
    Beinfeld, MC
    Greenblatt, DJ
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2000, 43 (01) : 41 - 54
  • [36] Cytochrome P450 3A pharmacogenetics: the road that needs traveled
    D A Flockhart
    J M Rae
    The Pharmacogenomics Journal, 2003, 3 : 3 - 5
  • [37] How important is intestinal cytochrome P450 3A metabolism?
    van Herwaarden, Antonius E.
    van Waterschoot, Robert A. B.
    Schinkel, Alfred H.
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (05) : 223 - 227
  • [38] Cytochrome P450 3A: Genetic polymorphisms and interethnic differences
    Krishna, DR
    Shekar, MS
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2005, 27 (08): : 559 - 567
  • [39] The use of cryopreserved human hepatocytes to study the induction of cytochrome P450 1A and 3A
    Garcia, M
    Rager, J
    Wang, Q
    Hidalgo, IJ
    Owen, A
    Li, JB
    DRUG METABOLISM REVIEWS, 2003, 35 : 120 - 120
  • [40] Characterization of the induction of rat microsomal cytochrome P450 by tacrine
    Sinz, MW
    Woolf, TF
    BIOCHEMICAL PHARMACOLOGY, 1997, 54 (03) : 425 - 427
12345