Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture

被引：18
|
作者：
JurimaRomet, M
Neigh, S
Casley, WL
机构：
[1] Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 1997年 / 16卷 / 04期
关键词：
cytochrome P450; retinoids; hepatocytes; rat;
D O I：
10.1177/096032719701600407
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
1 Rat hepatocytes cultured on a Matrigel matrix were exposed for 48 h to all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid or fenretinide, 2 Cytochrome P450 3A (CYP3A) RNA levels were increased by approximately eightfold in hepatocytes treated with the retinoids compared to control cultures. 3 CYP1A1 and CYP1A2 RNA levels were only slightly affected or unaffected by the retinoids. 4 The induction of CYP3A by these therapeutically-useful retinoids suggests that they may share a common mechanism for accelerated drug catabolism and acquired clinical resistance.
引用
收藏
页码：198 / 203
页数：6
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