Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

被引：41
|
作者：
Clauser, Sylvain [1 ,2 ]
Cramer-Borde, Elisabeth [3 ]
机构：
[1] Univ Versailles, St Quentin en Yvelines, France
[2] Hop Ambroise Pare, Serv Hematol Immunol, AP HP, F-92104 Boulogne, France
[3] Inst Cochin, INSERM, U567, Dept Hematol, Paris, France
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2009年 / 35卷 / 02期
关键词：
Platelet; electron; microscopy; diagnosis; WISKOTT-ALDRICH-SYNDROME; BERNARD-SOULIER-SYNDROME; CHEDIAK-HIGASHI-SYNDROME; STORAGE POOL DEFICIENCY; UROKINASE PLASMINOGEN-ACTIVATOR; HERMANSKY-PUDLAK SYNDROME; PROLONGED BLEEDING TIMES; ALPHA-GRANULE DEFICIENCY; VON-WILLEBRAND-FACTOR; IB-IX COMPLEX;
D O I：
10.1055/s-0029-1220329
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The electron microscope has proved to be a useful tool to study and understand the biology of platelets and to classify many platelet disorders. After a technical overview, this article reviews syndromes originating from platelet organelle, cytoskeleton, and membrane defects for which electron microscopy plays a role in the diagnostic process, such as gray platelet syndrome, Paris-Trousseau syndrome, storage pool diseases, MYH9-related thrombocytopenias, or Wiskott-Aldrich syndrome. Particular focus is given to the ultrastructural aspect of platelets in these disorders.
引用
收藏
页码：213 / 223
页数：11
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