Bergmann Glia, Long-Term Depression, and Autism Spectrum Disorder

被引：22

作者：

Chrobak, Adrian Andrzej ^{[1
,2
]}

Soltys, Zbigniew ^{[1
]}

机构：

[1] Jagiellonian Univ, Inst Zool, Dept Neuroanat, Gronostajowa St 9, PL-30387 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Fac Med, Kopernika St 21A, PL-31501 Krakow, Poland

来源：

MOLECULAR NEUROBIOLOGY | 2017年 / 54卷 / 02期

关键词：

Neuroglia; Plasticity; Radial glia; Excitotoxicity; Glutamate transporters; NEURONAL GLUTAMATE TRANSPORTERS; ADENOMATOUS POLYPOSIS-COLI; FIBRILLARY ACIDIC PROTEIN; CELL-SURFACE EXPRESSION; IN-SITU HYBRIDIZATION; PURKINJE-CELLS; MOTOR COORDINATION; CEREBELLAR CORTEX; MOUSE CEREBELLUM; ECTOPIC RELEASE;

D O I：

10.1007/s12035-016-9719-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bergmann glia (BG), a specific type of radial astrocytes in the cerebellum, play a variety of vital functions in the development of this structure. However, the possible role of BG in the development of abnormalities observed in individuals with autism spectrum disorder (ASD) seems to be underestimated. One of the most consistent findings observed in ASD patients is loss of Purkinje cells (PCs). Such a defect may be caused by dysregulation of glutamate homeostasis, which is maintained mainly by BG. Moreover, these glial cells are involved in long-term depression (LTD), a form of plasticity which can additionally subserve neuroprotective functions. The aim of presented review is to summarize the current knowledge about interactions which occur between PC and BG, with special emphasis on those which are relevant to the survival and proper functioning of cerebellar neurons.

引用

页码：1156 / 1166

页数：11

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