Kappe neurons, a novel population of olfactory sensory neurons

被引:62
|
作者
Ahuja, Gaurav [1 ]
Nia, Shahrzad Bozorg [1 ]
Zapilko, Veronika [1 ]
Shiriagin, Vladimir [1 ]
Kowatschew, Daniel [1 ]
Oka, Yuichiro [1 ]
Korsching, Sigrun I. [1 ]
机构
[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany
来源
SCIENTIFIC REPORTS | 2014年 / 4卷
关键词
CRYPT NEURONS; ZEBRAFISH; RECEPTOR; MICROVILLI; EPITHELIUM; GLOMERULI; EXPRESS; PROJECT; SINGLE;
D O I
10.1038/srep04037
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their G(o)-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.
引用
收藏
页数:8
相关论文
共 50 条
  • [11] Limit Cycles in a Model of Olfactory Sensory Neurons
    Xia, Yonghui
    Grasic, Mateja
    Huang, Wentao
    Romanovski, Valery G.
    INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2019, 29 (03):
  • [12] Axonal Regrowth of Olfactory Sensory Neurons In Vitro
    Sipione, Rebecca
    Liaudet, Nicolas
    Rousset, Francis
    Landis, Basile N.
    Hsieh, Julien Wen
    Senn, Pascal
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (16)
  • [13] Genomics of Mature and Immature Olfactory Sensory Neurons
    Nickell, Melissa D.
    Breheny, Patrick
    Stromberg, Arnold J.
    McClintock, Timothy S.
    JOURNAL OF COMPARATIVE NEUROLOGY, 2012, 520 (12) : 2608 - 2629
  • [14] Mice cloned from olfactory sensory neurons
    Eggan, E
    Baldwin, K
    Tackett, M
    Osborne, J
    Gogos, J
    Chess, A
    Axel, R
    Jaenisch, R
    NATURE, 2004, 428 (6978) : 44 - 49
  • [15] Role of Neurotransmitters in the Functioning of Olfactory Sensory Neurons
    E. V. Bigdai
    V. O. Samoilov
    Journal of Evolutionary Biochemistry and Physiology, 2022, 58 : 865 - 874
  • [16] Role of Neurotransmitters in the Functioning of Olfactory Sensory Neurons
    Bigdai, E., V
    Samoilov, V. O.
    JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2022, 58 (03) : 865 - 874
  • [17] Expression of transcriptional regulators in olfactory sensory neurons
    Sammeta, N.
    McClintock, T.
    CHEMICAL SENSES, 2006, 31 (05) : A134 - A134
  • [18] Transduction and signaling in olfactory sensory neurons.
    Firestein, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U47 - U47
  • [19] Axon guidance of olfactory sensory neurons in zebrafish
    Miyasaka, N
    Sato, Y
    Yoshihara, Y
    CHEMICAL SENSES, 2005, 30 : I92 - i93
  • [20] System identification of Drosophila olfactory sensory neurons
    Kim, Anmo J.
    Lazar, Aurel A.
    Slutskiy, Yevgeniy B.
    JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2011, 30 (01) : 143 - 161