The prevalence of undiagnosed and unrecognized primary hyperparathyroidism: A population-based analysis from the electronic medical record

被引:157
|
作者
Press, Danielle M. [1 ]
Siperstein, Allan E. [1 ]
Berber, Eren [1 ]
Shin, Joyce J. [1 ]
Metzger, Rosemarie [1 ]
Jin, Judy [1 ]
Monteiro, Rosebel [1 ]
Mino, Jeff [1 ]
Swagel, Warren [1 ]
Mitchell, Jamie C. [1 ]
机构
[1] Cleveland Clin Fdn, Cleveland, OH 44195 USA
关键词
EPIDEMIOLOGY; GUIDELINES; MANAGEMENT; SURGERY;
D O I
10.1016/j.surg.2013.06.051
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. The electronic medical record (EMR) of a large, tertiary referral center was examined to study the prevalence of undiagnosed and unrecognized primary hyperparathyroidism (PHPT). Methods. The EMR was queried for outpatient serum calcium > 10.5 mg/dL over a 2-year period. Results. Of 2.7 million patients, 54,198 (2%) had hypercalcemia (> 10.5 mg/dL). In a 2-year sample of 7,269 patients, 1.3% (95 patients) had a recorded diagnosis of PHPT, and 0.3% (16 patients) had parathyroidectomy. Of the remaining patients, parathyroid hormone (PTH) values were recorded in 32% (2,337 patients). Of patients with PTH measured, 71% (1,662 patients) had PHPT (PTH > 30 pg/mL). Patients with calcium of 11.1-11.5 mg/dL Were most likely to have PHPT (55%). Patients with calcium > 12 mg/dL were most likely to have PTH measured (52%). Of hypercalcemic patients, 67% never had PTH obtained, 28% of whom were likely to have PHPT. It is estimated that 43% of hypercalcemic patients are likely to have PHPT. The estimated prevalence of PHPT in the general population is 0.86%. Conclusion. PHPT is a more common disorder than previously documented. It is crucial to evaluate even mild hypercalcemia, because 43% of these patients have PHPT. PHPT is underdiagnosed and undertreated.
引用
收藏
页码:1232 / 1237
页数:6
相关论文
共 50 条
  • [31] Dyslipidemia Prevalence in Iranian Adult Men: The Impact of Population-Based Screening on the Detection of Undiagnosed Patients
    Mohammadbeigi, Abolfazl
    Moshiri, Esamil
    Mohammadsalehi, Narges
    Ansari, Hossein
    Ahmadi, Ali
    WORLD JOURNAL OF MENS HEALTH, 2015, 33 (03): : 167 - 173
  • [32] Prevalence and Potential Preventability of Adverse Drug Events - A Population-Based Medical Record Study of 4,995 Adults
    Hakkarainen, Katja M.
    Sundell, Karolina Andersson
    Jonsson, Anna K.
    Petzold, Max
    Hagg, Staffan
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2013, 22 : 469 - 469
  • [33] Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record
    Elhanan, Gai
    Kiser, Daniel
    Neveux, Iva
    Dabe, Shaun
    Bolze, Alexandre
    Metcalf, William J.
    Lu, James T.
    Grzymski, Joseph J.
    FRONTIERS IN GENETICS, 2022, 13
  • [34] Morbidity Associated With Primary Hyperparathyroidism-A Population-based Study With a Subanalysis on Vitamin D
    Soto-Pedre, Enrique
    Lin, Yeun Yi
    Soto-Hernaez, Jimena
    Newey, Paul J.
    Leese, Graham P.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2023, 108 (09): : E842 - E849
  • [35] Prevalence and incidence of primary hyperparathyroidism in Bahrain: A retrospective study from one medical center
    Abdulla, Jehan
    Suwaifi, Yasmeen M.
    NEUROENDOCRINOLOGY LETTERS, 2021, 42 (04) : 257 - 264
  • [36] Psoriasis Severity and the Prevalence of Major Medical Comorbidity A Population-Based Study
    Yeung, Howa
    Takeshita, Junko
    Mehta, Nehal N.
    Kimmel, Stephen E.
    Ogdie, Alexis
    Margolis, David J.
    Shin, Daniel B.
    Attor, Rosemary
    Troxel, Andrea B.
    Gelfand, Joel M.
    JAMA DERMATOLOGY, 2013, 149 (10) : 1173 - 1179
  • [37] Electronic Medical Record Inaccuracies: A Challenge For Population Based Lung Cancer Screening
    Wilshire, C. L.
    Fathi, J.
    Louie, B. E.
    Aye, R. W.
    Farivar, A. S.
    Vallieres, E.
    Gorden, J. A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191
  • [38] The prevalence of primary headache disorders in Russia: a countrywide population-based survey
    Ayzenberg, I.
    Katsarava, Z.
    Sborowski, A.
    Chernysh, M.
    Osipova, V.
    Tabeeva, G.
    Steiner, T. J.
    CEPHALALGIA, 2011, 31 (01) : 1 - 1
  • [39] The prevalence of primary headache disorders in Nepal: a nationwide population-based study
    Kedar Manandhar
    Ajay Risal
    Timothy J Steiner
    Are Holen
    Mattias Linde
    The Journal of Headache and Pain, 2015, 16
  • [40] Prevalence of Primary Sjogren's Syndrome in a US Population-Based Cohort
    Maciel, Gabriel
    Crowson, Cynthia S.
    Matteson, Eric L.
    Cornec, Divi
    ARTHRITIS CARE & RESEARCH, 2017, 69 (10) : 1612 - 1616