In vivo measurement of T1ρ dispersion in the human brain at 1.5 tesla

被引:53
|
作者
Borthakur, A [1 ]
Wheaton, AJ [1 ]
Gougoutas, AJ [1 ]
Akella, SVS [1 ]
Regatte, RR [1 ]
Charagundla, SR [1 ]
Reddy, R [1 ]
机构
[1] Univ Penn, Dept Radiol, Stellar Chance Labs B1, Philadelphia, PA 19104 USA
关键词
T1rho; dispersion; brain; relaxometry; SAR;
D O I
10.1002/jmri.20016
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To measure T-1rho relaxation times and TIP dispersion in the human brain in vivo. Materials and Methods: Magnetic resonance imaging (MRI) was performed on a 1.5-T GE Signa clinical scanner using the standard GE head coil. A fast spin-echo (FSE)-based T-1rho-weighted MR pulse sequence was employed to obtain images from five healthy male volunteers. Optimal imaging parameters were determined while considering both the objective of the study and the guarantee that radio-frequency (RF) power deposition during MR did not exceed Food and Drug Administration (FDA)-mandated safety levels. Results: T-1rho-weighted MR images showed excellent contrast between different brain tissues. These images were less blurred than corresponding T-2-weighted images obtained with similar contrast, especially in regions between brain parenchyma and cerebrospinal fluid (CSF). Average T-1rho values for white matter (WM), gray matter (GM), and CSF were 85 +/- 3, 99 +/- 1, and 637 +/- 78 msec, respectively, at a spin-locking field of 500 Hz. T-1rho is 30% higher in the parenchyma and 78% higher in CSF compared to the corresponding T-2 values. T-1rho dispersion was observed between spin-locking frequencies 0 and 500 Hz. Conclusion: T-1rho-weighted MRI provides images of the brain with superb contrast and detail. T-1rho values measured in the different brain tissues will serve as useful baseline values for analysis of T-1rho changes associated with pathology.
引用
收藏
页码:403 / 409
页数:7
相关论文
共 50 条
  • [31] Measurement of Glycine in Human Prefrontal Brain by Point-Resolved Spectroscopy at 7.0 Tesla In Vivo
    Choi, Changho
    Douglas, Deborah
    Hawesa, Halima
    Jindal, Ashish
    Storey, Charles
    Dimitrov, Ivan
    MAGNETIC RESONANCE IN MEDICINE, 2009, 62 (05) : 1305 - 1310
  • [32] Assessment of T1, T1ρ, and T2 values of the ulnocarpal disc in healthy subjects at 3 tesla
    Rauscher, Isabel
    Bender, Benjamin
    Groezinger, Gerd
    Luz, Oliver
    Pohmann, Rolf
    Erb, Michael
    Schick, Fritz
    Martirosian, Petros
    MAGNETIC RESONANCE IMAGING, 2014, 32 (09) : 1085 - 1090
  • [33] Reference values of myocardial native T1 and T2 mapping values in normal Indian population at 1.5 Tesla scanner
    Shaw, Manish
    Ojha, Vineeta
    Ganga, Kartik P.
    Malhi, Amarindar Singh
    Chandrashekhara, S. H.
    Kumar, Sanjeev
    Khan, Maroof Ahmad
    Jagia, Priya
    Sharma, Sanjiv
    INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2022, 38 (11): : 2403 - 2411
  • [34] Reference values of myocardial native T1 and T2 mapping values in normal Indian population at 1.5 Tesla scanner
    Manish Shaw
    Vineeta Ojha
    Kartik P. Ganga
    Amarindar Singh Malhi
    S. H. Chandrashekhara
    Sanjeev Kumar
    Maroof Ahmad Khan
    Priya Jagia
    Sanjiv Sharma
    The International Journal of Cardiovascular Imaging, 2022, 38 : 2403 - 2411
  • [35] dGEMRIC and Subsequent T1 Mapping of the Hip at 1.5 Tesla: Normative Data on Zonal and Radial Distribution in Asymptomatic Volunteers
    Bittersohl, Bernd
    Hosalkar, Harish S.
    Werlen, Stefan
    Trattnig, Siegfried
    Siebenrock, Klaus A.
    Mamisch, Tallal C.
    JOURNAL OF MAGNETIC RESONANCE IMAGING, 2011, 34 (01) : 101 - 106
  • [36] Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla
    Leah A. Gilligan
    Jonathan R. Dillman
    Jean A. Tkach
    Stavra A. Xanthakos
    Jacqueline K. Gill
    Andrew T. Trout
    Pediatric Radiology, 2019, 49 : 1018 - 1024
  • [37] SEX- AND AGE-DIFFERENCES IN NATIVE T1 RELAXATION TIMES IN HEALTHY ADULTS AT 1.5 AND 3.0 TESLA
    Rauhalammi, S.
    Barrientos, P. Hall
    Carrick, D.
    McComb, C.
    Mangion, K.
    Clerfond, G.
    McClure, J.
    Radjenovic, A.
    Berry, C.
    HEART, 2015, 101 : A16 - A16
  • [38] T1 correlates age: A short-TE MR relaxometry study in vivo on human cortical bone free water at 1.5 T
    Akbari, Atena
    Abbasi-Rad, Shahrokh
    Rad, Hamidreza Saligheh
    BONE, 2016, 83 : 17 - 22
  • [39] Water proton MR properties of human blood at 1.5 Tesla:: Magnetic susceptibility, T1, T2, T2* and non-Lorentzian signal behavior
    Spees, WM
    Yablonskiy, DA
    Oswood, MC
    Ackerman, JJH
    MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (04) : 533 - 542
  • [40] Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo
    Madan, Akshay
    Ganji, Sandeep K.
    An, Zhongxu
    Choe, Kevin S.
    Pinho, Marco C.
    Bachoo, Robert M.
    Maher, Elizabeth M.
    Choi, Changho
    MAGNETIC RESONANCE IN MEDICINE, 2015, 73 (06) : 2094 - 2099