Proof-of-Concept Study for an Enhanced Surrogate Marker of Endothelial Function in Diabetes

被引:0
|
作者
Dalan, R. [1 ,2 ,3 ]
Goh, S. [4 ]
Bing, Sun [1 ]
Seneviratna, A. [1 ]
Phua, C. T. [4 ]
机构
[1] Natl Healthcare Grp, Tan Tock Seng Hosp, Singapore, Singapore
[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
[3] Yong Loo Lin Sch Med, Singapore, Singapore
[4] Nanyang Polytech, Sch Engn, Singapore, Singapore
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
基金
英国医学研究理事会;
关键词
INTIMA-MEDIA THICKNESS; RADIAL ARTERY; RISK-FACTORS; BRACHIAL-ARTERY; CAROTID-ARTERY; CARDIOVASCULAR-DISEASE; DEPENDENT VASODILATION; DYSFUNCTION; CORONARY; FRAMINGHAM;
D O I
10.1038/s41598-018-26931-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distensibility of a distal vessel should be a good biomarker for subclinical disease. We have developed a device capable of measuring reactive hyperaemia induced changes in the radial artery flow, volumetric changes and accompanying effects on the vessel wall. The measurement is based on the magnetic flux disturbance upon haemodynamic modulation as blood flows through a uniformly applied magnetic field, and generates what we have termed the radial artery maximum distensibility index (RA-MDI). In a proof-of-concept study we found significant correlations between RA-MDI and cardiovascular risk factors, scoring systems and carotid artery intima-media thickness. Further large scale prospective studies need to be conducted to ascertain the correlations with cardiovascular events.
引用
收藏
页数:11
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