Monitoring treatment of acute kidney injury with damage biomarkers

被引:16
|
作者
Pianta, T. J. [1 ,2 ]
Succar, L. [1 ]
Davidson, T. [3 ]
Buckley, N. A. [4 ]
Endre, Z. H. [1 ]
机构
[1] Univ New South Wales, Prince Wales Clin Sch, Randwick, NSW, Australia
[2] Univ Melbourne, Northern Clin Sch, 185Cooper St, Epping, Vic 3076, Australia
[3] Prince Wales Hosp, Anat Pathol, Randwick, NSW, Australia
[4] Univ Sydney, Clin Pharmacol, Sydney, NSW 2006, Australia
基金
英国医学研究理事会;
关键词
Cisplatin; Alpha-lipoic acid; Acute tubular injury; Acute kidney injury; Biomarkers; ALPHA-LIPOIC ACID; CISPLATIN-INDUCED NEPHROTOXICITY; ACUTE-RENAL-FAILURE; URINARY BIOMARKERS; OXIDATIVE STRESS; CYSTATIN C; ANTIOXIDANT; AKI; EXPRESSION; EXCRETION;
D O I
10.1016/j.toxlet.2017.01.001
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Background: Damage biomarkers may identify mechanisms and sites of acute kidney injury (AKI). However, the utility of novel AKI biomarkers differs by context, and their utility for monitoring treatment of AKI is unknown. We hypothesized that selected AKI biomarkers would facilitate monitoring of mechanism-specific treatment. We examined this using a panel of biomarkers to monitor cisplatininduced AKI treatment with alpha-lipoic acid (alpha-LA) that has previously been demonstrated to ameliorate cisplatin induced AKI. Methods: AKI was induced in male Sprague Dawley rats using cisplatin (6 mg/kg) in the presence or absence of a single dose of alpha-LA (100 mg/kg). A panel of 12 urinary kidney damage biomarkers (CystatinC, NGAL albumin, alpha-l-acid glycoprotein, clusterin, KIM-1, osteopontin, total protein, cytochrome C, epidermal growth factor, interleukin-18 and malondialdehyde was examined as well as histological injury, serum creatinine and cystatin C, and clinical parameters. Results: Cisplatin treatment modified all parameters, except interleukin-18 and malondialdehyde, with each parameter demonstrating a different temporal profile. alpha-LA treatment attenuated renal tubular injury scores (P < 0.05), decreased peak serum creatinine (p = 0.004) and cystatin C (p = 0.04), and urinary damage biomarkers of proximal tubular injury (Cystatin C, NGAL, albumin, and alpha-l-acid glycoprotein). Other urinary biomarkers were not modified. Neither alpha-LA alone, nor the cisplatin vehicle (DMSO) modified biomarker profiles. Conclusions: alpha-LA treatment ameliorated cisplatin-induced AKI. Protection was demonstrated by reduced structural damage, improved glomerular filtration and reduced excretion of urinary biomarkers of proximal tubular damage. Effective treatment of AKI can be monitored by site and perhaps by mechanism-specific kidney damage biomarkers.(C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:63 / 70
页数:8
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