Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis

被引:203
|
作者
Hedstrom, Anna K. [1 ]
Baarnhielm, Maria [2 ]
Olsson, Tomas [2 ]
Alfredsson, Lars [1 ]
机构
[1] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, S-10401 Stockholm, Sweden
基金
英国医学研究理事会;
关键词
CIGARETTE-SMOKING; BLOOD; AXONS;
D O I
10.1212/WNL.0b013e3181b59c40
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The aim of this study was to estimate the influence of tobacco smoking and Swedish snuff use on the risk of developing multiple sclerosis (MS). Methods: A population-based case-control study was performed in Sweden, using incident cases of MS (902 cases and 1,855 controls). A case was defined as a subject from the study base who had received a diagnosis of MS, and controls were randomly selected from the study base. The incidence of MS among smokers was compared with that of never-smokers. We also investigated whether the use of Swedish snuff had an impact on the risk of developing MS. Results: Smokers of both sexes had an increased risk of developing MS (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.2-1.7 for women, and OR 1.8, 95% CI 1.3-2.5 for men). The increased risk was apparent even among subjects who had previously smoked moderately (<= 5 pack-years) prior to index, and the risk increased with increasing cumulative dose (p < 0.0001). The increased risk for MS associated with smoking remained up to 5 years after stopping smoking. In contrast, taking Swedish snuff for more than 15 years decreased the risk of developing MS (OR 0.3, 95% CI 0.1-0.8). Conclusions: Smokers of both sexes run an increased risk of developing multiple sclerosis (MS), and the risk increases with cumulative dose of smoking. However, the use of Swedish snuff is not associated with elevated risk for MS, which may indicate that nicotine is not the substance responsible for the increased risk of developing MS among smokers. Neurology (R) 2009; 73: 696-701
引用
收藏
页码:696 / 701
页数:6
相关论文
共 50 条
  • [31] Psychiatric Correlates of Snuff and Chewing Tobacco Use
    Fu, Qiang
    Vaughn, Michael G.
    Wu, Li-Tzy
    Heath, Andrew C.
    PLOS ONE, 2014, 9 (12):
  • [32] VOLATILE N-NITROSAMINES IN SNUFF AND CHEWING TOBACCO ON THE SWEDISH MARKET
    OSTERDAHL, BG
    SLORACH, SA
    FOOD AND CHEMICAL TOXICOLOGY, 1983, 21 (06) : 759 - 762
  • [33] Comorbidity increases the risk of hospitalizations in multiple sclerosis
    Marrie, Ruth Ann
    Elliott, Lawrence
    Marriott, James
    Cossoy, Michael
    Tennakoon, Aruni
    Yu, Nancy
    NEUROLOGY, 2015, 84 (04) : 350 - 358
  • [34] THE USE OF CHEWING TOBACCO AND SNUFF IN CANADA, 1986
    MILLAR, WJ
    CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE, 1989, 80 (02): : 131 - 135
  • [35] Smoke exposure increases the risk for multiple sclerosis
    Sundstrom, P.
    Nystrom, L.
    Hallmans, G.
    EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 (06) : 579 - 583
  • [36] Grandmaternal smoking increases asthma risk in grandchildren: A nationwide Swedish cohort
    Lodge, C. J.
    Braback, L.
    Lowe, A. J.
    Dharmage, S. C.
    Olsson, D.
    Forsberg, B.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2018, 48 (02): : 167 - 174
  • [37] Snuff use and smoking in Finnish Olympic athletes
    Alaranta, A.
    Alaranta, H.
    Patja, K.
    Palmu, P.
    Prattala, R.
    Martelin, T.
    Helenius, I.
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2006, 27 (07) : 581 - 586
  • [38] Tobacco smoking, snuff dipping and the risk of cutaneous squamous cell carcinoma: a nationwide cohort study in Sweden
    Å Odenbro
    R Bellocco
    P Boffetta
    B Lindelöf
    J Adami
    British Journal of Cancer, 2005, 92 : 1326 - 1328
  • [39] Tobacco smoking, snuff dipping and the risk of cutaneous squamous cell carcinoma:: a nationwide cohort study in Sweden
    Odenbro, Å
    Bellocco, R
    Boffetta, P
    Lindelöf, B
    Adami, J
    BRITISH JOURNAL OF CANCER, 2005, 92 (07) : 1326 - 1328
  • [40] Use of smokeless tobacco is a risk factor for cigarette smoking
    Severson, Herbert H.
    Forrester, Kathleen K.
    Biglan, Anthony
    NICOTINE & TOBACCO RESEARCH, 2007, 9 (12) : 1331 - 1337