Clinical, histological and immunopathological features of 58 patients with subacute cutaneous lupus erythematosus - A review by the Italian Group of Immunodermatology

被引:51
|
作者
Parodi, A
Caproni, M
Cardinali, C
Bernacchi, E
Fuligni, A
De Panfilis, G
Zane, C
Papini, M
Veller, FC
Vaccaro, M
Fabbri, P
机构
[1] Univ Florence, Dermatol Clin 2, I-50121 Florence, Italy
[2] Univ Genoa, Sez Dermatol, DISEM, Genoa, Italy
[3] Spedali Civil Brescia, Div Dermatol, I-25125 Brescia, Italy
[4] Univ Perugia, Sez Dermatol Terni, I-06100 Perugia, Italy
[5] Univ Padua, Dermatol Clin, I-35100 Padua, Italy
[6] Univ Messina, Dermatol Clin, I-98100 Messina, Italy
关键词
lupus erythematosus; subacute cutaneous; psoriasiform lesions; annular lesions;
D O I
10.1159/000018307
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of cutaneous lupus erythematosus clinically characterized by psoriasiform and/or annular lesions and by a mild or absent systemic involvement. Objective: The Italian Group of Immunodermatology of the Italian Society of Dermatology and Venereology reviewed the cases of SCLE seen in 10 years (1987-1996). Patients: Forty-six women and 12 men have been retrospectively studied, 42% had annular lesions, 39% psoriasiform ones and 16% both. Results: Lesions were mainly localized on the neck and face and relapsed in spring and autumn. Seventeen patients had 4 or more American College of Rheumatology criteria and could be classified as having systemic lupus erythematosus. The most frequent histopathological alterations were epidermal atrophy, hydropic degeneration of the basal layer and perivascular lymphocytic infiltrate. Deposits of immunoglobulins and C3 at the dermo-epidermal junction on the clinically involved skin were present in 86% of the patients. Dust-like particles in the epidermis were only found in 3% of cases. Anti-Ro/SSA antibodies were found in 71% of the cases and anti-dsDNA only in 5% of cases. Conclusions: SCLE is a particular subset of cutaneous lupus erythematosus with peculiar clinical and immunopathological features. Copyright (R) 2000 S. Karger AG, Basel.
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页码:6 / 10
页数:5
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