De novo Crohn's Disease Following Orthotopic Liver Transplantation: A Case Report and Literature Review

被引：7

作者：

Naito, Takeo ^{[1
]}

Shiga, Hisashi ^{[1
]}

Endo, Katsuya ^{[1
]}

Kuroha, Masatake ^{[1
]}

Kakuta, Yoichi ^{[1
]}

Kinouchi, Yoshitaka ^{[2
]}

Shimosegawa, Tooru ^{[1
]}

机构：

[1] Tohoku Univ, Div Gastroenterol, Grad Sch Med, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Hlth Adm Ctr, Ctr Adv Higher Educ, Sendai, Miyagi 980, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 02期

关键词：

Crohn's disease; de novo Crohn's disease; orthotopic liver transplantation; immunosuppressive agents; INFLAMMATORY-BOWEL-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; REGULATORY T-CELLS; OF-THE-LITERATURE; ULCERATIVE-COLITIS; CYTOMEGALOVIRUS-INFECTION; CASE SERIES; ORGAN-TRANSPLANTATION; ALLOGRAFT RECIPIENTS; ORAL TACROLIMUS;

D O I：

10.2169/internalmedicine.54.3156

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of de novo Crohn's disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.

引用

页码：199 / 204

页数：6

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