A New Cycloartane Glucoside from Rhizophora stylosa

被引:1
|
作者
Phan Thi Thanh Huong [1 ]
Chau Ngoc Diep [1 ]
Nguyen Van Thanh [1 ]
Vu Anh Tu [1 ]
Tran Hong Hanh [1 ]
Nguyen The Cuong [2 ]
Nguyen Phuong Thao [1 ]
Nguyen Xuan Cuong [1 ]
Do Thi Thao [3 ]
Tran Huy Thai [2 ]
Nguyen Hoai Nam [1 ]
Ninh Khac Ban [1 ]
Phan Van Kiem [1 ]
Chau Van Minh [1 ]
机构
[1] Vietnam Acad Sci & Technol, Inst Marine Biochem IMBC, Hanoi, Vietnam
[2] VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam
[3] VAST, Inst Biotechnol, Hanoi, Vietnam
关键词
Rhizophora stylosa; Rhizophoraceae; Cycloartane; Rhizostyloside; Cytotoxic activity; Caspase-3/7; GLYCOSIDES; CONSTITUENTS; DERIVATIVES; MULTIFLORA; ROOTS;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, NOESY) and HR-BSI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.
引用
收藏
页码:1255 / 1257
页数:3
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