Parkinson's disease in the single-cell era

被引：5
|
作者：
Arenas, Ernest [1 ]
机构：
[1] Karolinska Inst, MBB, Mol Neurobiol, Stockholm, Sweden
来源：
NATURE NEUROSCIENCE | 2022年 / 25卷 / 05期
关键词：
D O I：
10.1038/s41593-022-01069-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Degeneration of dopaminergic neurons in the substantia nigra is a pathological hallmark of Parkinson's disease (PD). However, not all dopamine-producing neurons degenerate. Kamath, Abdulraouf et al. find that there are ten transcriptionally defined dopaminergic subpopulations in the human substantia nigra, but only one carries significant PD genetic risk and is vulnerable to neurodegeneration in PD.
引用
收藏
页码：536 / 538
页数：3
相关论文
共 50 条
  • [21] An era of single-cell genomics consortia
    Ando, Yoshinari
    Kwon, Andrew Tae-Jun
    Shin, Jay W.
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, 52 (09): : 1409 - 1418
  • [22] Immunology in the Era of Single-Cell Technologies
    Efremova, Mirjana
    Vento-Tormo, Roser
    Park, Jong-Eun
    Teichmann, Sarah A.
    James, Kylie R.
    ANNUAL REVIEW OF IMMUNOLOGY, VOL 38, 2020, 38 : 727 - 757
  • [23] An era of single-cell genomics consortia
    Yoshinari Ando
    Andrew Tae-Jun Kwon
    Jay W. Shin
    Experimental & Molecular Medicine, 2020, 52 : 1409 - 1418
  • [24] Microglia Heterogeneity in the Single-Cell Era
    Masuda, Takahiro
    Sankowski, Roman
    Staszewski, Ori
    Prinz, Marco
    CELL REPORTS, 2020, 30 (05): : 1271 - 1281
  • [25] Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
    Pingping Wang
    Lifen Yao
    Meng Luo
    Wenyang Zhou
    Xiyun Jin
    Zhaochun Xu
    Shi Yan
    Yiqun Li
    Chang Xu
    Rui Cheng
    Yan Huang
    Xiaoyu Lin
    Kexin Ma
    Huimin Cao
    Hongxin Liu
    Guangfu Xue
    Fang Han
    Huan Nie
    Qinghua Jiang
    Cell Discovery, 7
  • [26] Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson's disease
    Wang, Pingping
    Yao, Lifen
    Luo, Meng
    Zhou, Wenyang
    Jin, Xiyun
    Xu, Zhaochun
    Yan, Shi
    Li, Yiqun
    Xu, Chang
    Cheng, Rui
    Huang, Yan
    Lin, Xiaoyu
    Ma, Kexin
    Cao, Huimin
    Liu, Hongxin
    Xue, Guangfu
    Han, Fang
    Nie, Huan
    Jiang, Qinghua
    CELL DISCOVERY, 2021, 7 (01)
  • [27] Single-Cell Cortical Transcriptomics Reveals Common and Distinct Changes in Cell-Cell Communication in Alzheimer's and Parkinson's Disease
    Le Bars, Sophie
    Glaab, Enrico
    MOLECULAR NEUROBIOLOGY, 2025, 62 (03) : 2655 - 2673
  • [28] Unraveling the transcriptomic signatures of Parkinson's disease and major depression using single-cell and bulk data
    Christodoulou, Christiana C.
    Onisiforou, Anna
    Zanos, Panos
    Papanicolaou, Eleni Zamba
    FRONTIERS IN AGING NEUROSCIENCE, 2023, 15
  • [29] Transcriptomics of Human Brain Tissue in Parkinson's Disease: a Comparison of Bulk and Single-cell RNA Sequencing
    Fiorini, Michael R.
    Dilliott, Allison A.
    Thomas, Rhalena A.
    Farhan, Sali M. K.
    MOLECULAR NEUROBIOLOGY, 2024, 61 (11) : 8996 - 9015
  • [30] Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort
    Phongpreecha, Thanaphong
    Mathi, Kavita
    Cholerton, Brenna
    Fox, Eddie J.
    Sigal, Natalia
    Espinosa, Camilo
    Reincke, Momsen
    Chung, Philip
    Hwang, Ling-Jen
    Gajera, Chandresh R.
    Berson, Eloise
    Perna, Amalia
    Xie, Feng
    Shu, Chi-Hung
    Hazra, Debapriya
    Channappa, Divya
    Dunn, Jeffrey E.
    Kipp, Lucas B.
    Poston, Kathleen L.
    Montine, Kathleen S.
    Maecker, Holden T.
    Aghaeepour, Nima
    Montine, Thomas J.
    MOLECULAR NEURODEGENERATION, 2024, 19 (01)
12345