Copper-Catalyzed Borylative Difunctionalization of π-Systems

被引：196
|
作者：
Whyte, Andrew [1 ]
Torelli, Alexa [1 ]
Mirabi, Bijan [1 ]
Zhang, Anji [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada
来源：
ACS CATALYSIS | 2020年 / 10卷 / 19期
基金：
加拿大自然科学与工程研究理事会;
关键词：
copper; boronates; difunctionalization; stereoselectivity; catalysis; SUBSTITUTED STEREOGENIC CARBON; CROSS-COUPLING REACTIONS; C-H CYANATION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; IN-SITU; DIASTEREOSELECTIVE SYNTHESIS; COPPER(I)-CATALYZED REACTION; BORYLATION/ORTHO-CYANATION;
D O I：
10.1021/acscatal.0c02758
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Organoboronates represent a cornerstone functional group in modern synthesis owing to their unique reactivity and divergent synthetic capability. Copper catalysis has become one of the most powerful methods to stereoselectively install boron across diverse pi-systems. Additionally, this method affords tremendous versatility enabled by difunctionalization of the pi-system by the addition of an electrophile. This review covers known electrophiles to intercept catalytic intermediates in borylative difunctionalization strategies that have been reported up to the end of May 2020.
引用
收藏
页码：11578 / 11622
页数：45
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