An efficient, highly enantioenriched route to L-carnitine and α-lipoic acid via hydrolytic kinetic resolution

被引：18
|
作者：
Bose, D. Sublias [1 ]
Fatima, Liyakat [1 ]
Rajender, Salla [1 ]
机构：
[1] Indian Inst Chem Technol, Fine Chem Lab, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2006年 / 11卷 / 11期
关键词：
L-carnitine; alpha-lipoic acid; hydrolytic kinetic resolution; terminal epoxide; enantioenriched;
D O I：
10.1055/s-2006-942363
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and practical approach for the synthesis of C-4 chiral building blocks using Jacobsen's hydrolytic kinetic resolution technique to resolve terminal epoxides and diols in high enantiomeric excess and excellent yields is described. The utilization of these building blocks for the synthesis of biologically important natural products L-carnitine and alpha-lipoic acid is illustrated.
引用
收藏
页码：1863 / 1867
页数：5
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