Quaternary Ammonium Derivatives of 2-Aminothiophene-3-Carboxylates with Antimicrobial Activity

被引：0

作者：

Khachatryan, D. S. ^{[1
]}

Kolotaev, A., V ^{[1
]}

Osipov, V. N. ^{[1
]}

Yashkir, V. A. ^{[2
]}

Matevosyan, K. R. ^{[3
]}

机构：

[1] NRC Kurchatov Inst IREA, Bogorodsky Val 3, Moscow 107076, Russia

[2] Minist Hlth Russia, FSBI SCEVIP, Petrovsky Blvd 8,Bld 2, Moscow 127051, Russia

[3] Mendeleev Univ Chem Technol Russia, Miusskaya Pl 9, Moscow 125047, Russia

来源：

PROCEEDINGS OF THE II INTERNATIONAL CONFERENCE: MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2018) | 2019年 / 2063卷

关键词：

D O I：

10.1063/1.5087355

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Reaction of alkyl chlorides and N-benzylimidazole was conducted by refluxing them in dioxane. The synthesized product was characterized using H-1-NMR. The reaction yielded white solid quaternary ammonium salts (QAS) in 31-82%. QAS have been widely researched its activity as antimicrobial and antibacterial. The substitution of the functional groups on the QAS structure affects its biological activity. Antimicrobial activity of QAS was assayed by the method of serial twofold dilutions in a liquid nutrient medium. According to the results, QAS could potentially be developed as a new drug candidate for the treatment of microbial infections.

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页数：5

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