Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

被引：130

作者：

Mathew, V.

Keshavayya, J. ^{[1
]}

Vaidya, V. P.

机构：

[1] Kuvempu Univ, Dept Studies Chem, Shimoga 577451, Karnataka, India

[2] Acharya & BM Reddy Coll Pharm, Bangalore, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 09期

关键词：

4-amino triazoles; triazolo thiadiazoles; phosphorous oxychloride; spectral characterization; pharmacological activities;

D O I：

10.1016/j.ejmech.2006.03.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadizoles were prepared by the condensation of 4-amino-3-aryl/aralkyl substituted5-mercapto-1,2,4-triazoles 3(a-c) with various substituted aromatic/hetero aromatic acids through a single step reaction. Elemental analysis, IR, H-1 NMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized triazolo thiadiazoles investigated for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed moderate antimicrobial activity against various tested bacterial and fungal strains. None of the synthesized compounds have significant anti-inflammatory and analgesic activities. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：1048 / 1058

页数：11

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