The role of mitochondria in ischemia/reperfusion injury in organ transplantation

被引：128
|
作者：
Jassem, W [1 ]
Heaton, ND [1 ]
机构：
[1] Kings Coll Hosp London, Inst Liver Studies, Liver Transplant Unit, London SE5 9RS, England
来源：
KIDNEY INTERNATIONAL | 2004年 / 66卷 / 02期
关键词：
apoptosis; organ preservation; transplant;
D O I：
10.1111/j.1523-1755.2004.761_9.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitochondria may be critical organelles, since they undergo major changes that may contribute to the injury occurring during I/R.
引用
收藏
页码：514 / 517
页数：4
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