Fluorescence diffuse optical tomography using upconverting nanoparticles

被引：48
|
作者：
Xu, Can T. [1 ]
Axelsson, Johan [1 ]
Andersson-Engels, Stefan [1 ]
机构：
[1] Lund Univ, Dept Phys, S-22100 Lund, Sweden
来源：
APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 25期
基金：
瑞典研究理事会;
关键词：
biological tissues; fluorescence; nanobiotechnology; nanoparticles; optical tomography; phantoms; photoluminescence; sodium compounds; thulium; ytterbium; yttrium compounds; SMALL ANIMALS; QUANTUM DOTS;
D O I：
10.1063/1.3156857
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] In vivo luminescence imaging and tomography using upconverting nanoparticles as contrast agents
    Andersson-Engels, Stefan
    Liu, Haichun
    Xu, Can T.
    Svenmarker, Pontus
    Gisselsson, Anna
    Kjellman, Pontus
    Andersson, Linda
    in't Zandt, Rene
    Olsson, Fredrik
    Fredriksson, Sarah
    2012 ASIA COMMUNICATIONS AND PHOTONICS CONFERENCE (ACP), 2012,
  • [22] Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data
    Perez-Juste Abascal, Juan Felipe
    Aguirre, Juan
    Chamorro-Servent, Judit
    Schweiger, Martin
    Arridge, Simon
    Ripoll, Jorge
    Vaquero, Juan J.
    Desco, Manuel
    JOURNAL OF BIOMEDICAL OPTICS, 2012, 17 (03)
  • [23] Model reduction using wavelet multiresolution technique applied to fluorescence diffuse optical tomography
    Landragin-Frassati, Anne
    Dinten, Jean-Marc
    Georges, Didier
    Da Silva, Anabela
    APPLIED OPTICS, 2009, 48 (36) : 6878 - 6892
  • [24] Diffuse optical fluorescence tomography using time-resolved data acquired in transmission
    Leblond, Frederic
    Fortier, Simon
    Friedlander, Michael P.
    MULTIMODAL BIOMEDICAL IMAGING II, 2007, 6431
  • [25] Noncontact fluorescence diffuse optical tomography off heterogeneous media
    Herve, L.
    Koenig, A.
    Da Silva, A.
    Berger, M.
    Boutet, J.
    Dinten, J. M.
    Peltie, P.
    Rizo, P.
    APPLIED OPTICS, 2007, 46 (22) : 4896 - 4906
  • [26] Free space ultrasound guided fluorescence diffuse optical tomography
    Lo, Pei-An
    Chiang, Huihua Kenny
    PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017, 2017, 10064
  • [27] Intrinsic optical sectioning with upconverting nanoparticles
    Sorbello, C.
    Etchenique, R.
    CHEMICAL COMMUNICATIONS, 2018, 54 (15) : 1861 - 1864
  • [28] Construction of the Jacobian matrix for fluorescence diffuse optical tomography using a perturbation Monte Carlo method
    Zhang, Xiaofeng
    Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2012, 8216
  • [29] Development of image reconstruction algorithms for fluorescence diffuse optical tomography using total light approach
    Okawa, S.
    Yamamoto, H.
    Miwa, Y.
    Yamada, Y.
    DIFFUSE OPTICAL IMAGING III, 2011, 8088
  • [30] Performance evaluation of adaptive meshing algorithms for fluorescence diffuse optical tomography using experimental data
    Zhou, Lu
    Yazici, Birsen
    Ale, Angelique B. F.
    Ntziachristos, Vasilis
    OPTICS LETTERS, 2010, 35 (22) : 3727 - 3729
12345