A study on the regio- and stereoselectivity in palladium-catalyzed cyclizations of alkenes and alkynes bearing bromoaryl and nucleophilic groups

被引：30
|
作者：
Bruyère, D [1 ]
Bouyssi, D [1 ]
Balme, G [1 ]
机构：
[1] Univ Lyon 1, CNRS, UMR 5181, Lab Chim Organ 1,CPE, F-69622 Villeurbanne, France
来源：
TETRAHEDRON | 2004年 / 60卷 / 18期
关键词：
stereoselectivity; biscyclization; palladium;
D O I：
10.1016/j.tet.2004.03.023
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have studied the remarkable dependence of the stereochemistry of the cyclization on the double bond geometry and of the effect of the bulkiness of the nucleophile on the regiochemistry of the palladium mediated cyclization of alkenes bearing aryl bromides and nucleophiles. In contrast. the cyclization of the acetylenic homologous substrates is not dependent on the nature of the nucleophile. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4007 / 4017
页数：11
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