Combinatorial Crystal Synthesis: Structural Landscape of Phloroglucinol:1,2-bis(4-pyridyl)ethylene and Phloroglucinol:Phenazine

被引：39
|
作者：
Dubey, Ritesh [1 ]
Desiraju, Gautam R. [1 ]
机构：
[1] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 48期
关键词：
cocrystals; combinatorial chemistry; crystal structure landscape; polymorphism; supramolecular synthons; CO-CRYSTALS; TERNARY COCRYSTALS; ACID; STACKING; ISONICOTINAMIDE; POLYMORPHISM; CHEMISTRY;
D O I：
10.1002/anie.201402668
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A large number of crystal forms, polymorphs and pseudopolymorphs, have been isolated in the phloroglucinol-dipyridylethylene (PGL:DPE) and phloroglucinol-phenazine (PGL:PHE) systems. An understanding of the intermolecular interactions and synthon preferences in these binary systems enables one to design a ternary molecular solid that consists of PGL, PHE, and DPE, and also others where DPE is replaced by other heterocycles. Clean isolation of these ternary cocrystals demonstrates synthon amplification during crystallization. These results point to the lesser likelihood of polymorphism in multicomponent crystals compared to single-component crystals. The appearance of several crystal forms during crystallization of a multicomponent system can be viewed as combinatorial crystal synthesis with synthon selection from a solution library. The resulting polymorphs and pseudopolymorphs that are obtained constitute a crystal structure landscape.
引用
收藏
页码：13178 / 13182
页数：5
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